Caution when used for monotherapy in patients w/ complicated intra-abdominal infections secondary to clinically apparent intestinal perforation; w/ known hypersensitivity to tetracyclines. Consider pseudomembranous colitis in patients w/ diarrhea. Carefully monitor patients during therapy to prevent superinfections. Monitor patients w/ severe hepatic impairment. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn <18 yr.