Tygacil

Tygacil Caution For Usage

tigecycline

Manufacturer:

Pfizer
Full Prescribing Info
Caution For Usage
Preparation and Handling: The lyophilized powder should be reconstituted with 5.3 mL of 0.9% sodium chloride injection, USP or 5% dextrose injection, USP, or Lactated Ringer's injection, USP, to achieve a concentration of 10 mg/mL of tigecycline. The vial should be gently swirled until the drug dissolves. Withdraw 5 mL of the reconstituted solution from the vial and add to a 100-mL IV bag for infusion. For a 100-mg dose, reconstitute using 2 vials into a 100-mL IV bag.
(Note: The vial contains a 6% overage. Thus, 5 mL of reconstituted solution is equivalent to 50 mg of Tygacil). The reconstituted solution should be yellow to orange in colour; if not, the solution should be discarded. Parenteral drug products should be inspected visually for particulate matter and discolouration (eg, green or black) prior to administration whenever solution and container permit. Once reconstituted, tigecycline may be stored at room temperature for up to 24 hrs (up to 6 hrs in the vial and the remaining time in the IV bag). Alternatively, tigecycline mixed with 0.9% sodium chloride injection, USP, or 5% dextrose injection, USP may be stored at 2-8°C (36-46°F) for up to 48 hrs following immediate transfer of the reconstituted solution into the IV bag.
Tygacil may be administered IV through a dedicated line or through a Y-site. If the same IV line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of Tygacil with either 0.9% sodium chloride injection, USP or 5% dextrose injection, USP. Injection should be made with an infusion solution compatible with tigecycline and with any other drug(s) administered via this common line (see Compatibilities/Incompatibilities under Interactions).
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