Tygacil Dosage/Direction for Use



Full Prescribing Info
Dosage/Direction for Use
The recommended dosage regimen for Tygacil is an initial dose of 100 mg, followed by 50 mg every 12 hrs. IV infusions of Tygacil should be administered over approximately 30-60 min every 12 hrs.
The recommended duration of treatment with Tygacil for complicated skin and skin structure infections or for complicated intra-abdominal infections is 5-14 days. The duration of therapy should be guided by the severity and site of the infection and the patient's clinical and bacteriological progress.
Hepatic Impairment: No dosage adjustment is warranted in patients with mild to moderate hepatic impairment (Child-Pugh A and Child-Pugh B). In patients with severe hepatic impairment (Child-Pugh C), the dose of Tygacil should be reduced to 100 mg followed by 25 mg every 12 hrs. Patients with severe hepatic impairment (Child-Pugh C) should be treated with caution and monitored for treatment response. (See Pharmacokinetics: Special Populations under Actions and Use in Patients with Hepatic Impairment under Precautions.)
Renal Impairment: No dosage adjustment of Tygacil is necessary in patients with renal impairment or in patients undergoing hemodialysis. (See Pharmacokinetics: Special Populations and Use in Patients with Renal Impairment under Actions.)
Children: Safety and effectiveness in patients <18 years have not been established. Therefore, use in patients <18 years is not recommended. (See Warnings.)
No dosage adjustment of Tygacil is necessary based on age, gender or race. (See Pharmacokinetics: Special Populations under Actions and Use in the elderly under Precautions.)
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