Prothrombin time or other suitable anticoagulation test should be monitored if tigecycline is administered with warfarin (see Pharmacokinetics: Drug-Drug Interactions under Actions).
Concurrent use of antibiotics with oral contraceptives may render oral contraceptives less effective.
Drug/Laboratory Test Interactions: There are no reported drug-laboratory test interactions.
Compatibilities/Incompatibilities: Compatible IV solutions include 0.9% sodium chloride injection, USP and 5% dextrose injection, USP and Lactated Ringer's injection, USP. When administered through a Y-site, Tygacil is compatible with the following drugs or diluents when used with either 0.9% sodium chloride injection, USP, or 5% dextrose injection, USP and administered simultaneously through the same line: Amikacin, dobutamine, dopamine HCl, gentamicin, haloperidol, Lactated Ringer's, lidocaine HCl, metoclopropramide, morphine, norepinephrine, piperacillin/tazobactam (EDTA formulation), potassium chloride, propofol, ranitidine HCl and tobramycin.
The following drugs should not be administered simultaneously through the same Y-site as Tygacil: Amphotericin B, amphotericin B lipid complex, diazepam, esomeprazole and omeprazole.