Ulcron

Ulcron

sucralfate

Manufacturer:

Coronet
Full Prescribing Info
Contents
Sucralfate.
Description
Each tablet contains: Sucralfate 500 mg.
Each measurement spoonful (5 ml) of suspension contains: Sucralfate 500 mg.
Action
Pharmacology: ULCRON contains sucralfate, a complex substance from a sucrose sulfate and aluminium hydroxide.
Sucralfate is not significantly absorbed from the gastro-intestinal tract and the from of the absorbed dissaccharide sulfate is excreted through urine.
ULCRON promotes a local action of accelerating the healing of gastric and duodenal ulcers.
The underlying studies indicate that ULCRON (sucralfate) has a working mechanism as follows: 1. Forming a complex with protein exudation at the ulcer site.
2. Forming a layer coating with albumin that blocks the diffusion of the hydrogen ions.
3. Trials in men indicate that medication with ULCRON at the recommended dosage of 2 tablets, 3-4 times a day will result in the inhibition of pepsin activity in the gastric juice up to 32 %.
Observation on the previously mentioned description shows that in the cases of gastric ulcers medication, sucralfate does not function as antacids. Instead, it works to form an ulcer adherent complex that covers the ulcer site. In this way are the ulcers protected against barrier breakers as gastric juice, pepsin and bile salts.
Indications/Uses
Gastric and duodenal ulcers; Chronic Gastritis.
Dosage/Direction for Use
Tablet: Adults: 2 tablets, 3-4 times a day in the intervals of meal time and in bed time, or depending on doctor's intructions.
Maximum dose per day: 8 gr.
Short term therapy may be done up to 8 weeks.
Suspensions: Adults: 2 measurement spoonfuls 4 times a day.
Given 1 hour before meals or 2 hours after meals and at bedtime.
Treatment should be continue, except when endoscopic examination or X-rays had shown the healing.
Contraindications
Patients known hypersensitive to this drug.
Patients of serious renal impairment.
Special Precautions
Medication to patients of renal impairment should be done with caution.
Long term therapy in patients on phosphate diet may cause osteomalacia.
If other antacids are concomitantly needed, there should be an interval of 30 minutes between the two preparations to avoid their interactions.
Use in Pregnancy & Lactation: Caution should be exercised when given during pregnancy or lactation, and it can be done only in emergency cases.
Use in Children: Its safety and effectiveness in children has not yet been known.
Use In Pregnancy & Lactation
Caution should be exercised when given during pregnancy or lactation, and it can be done only in emergency cases.
Side Effects
The incidence of side effects from sucralfate is very low and among those reported are: Constipation; Diarrhea; Nausea; Gastric disturbances; Dry mouth; Dizziness; Skin disturbances.
Drug Interactions
Sucralfate may interfere with the absorption of other drugs and it has been suggested that there should be an interval of 2 hours between the administration of sucralfate and other concurrent medication.
Concomitant use with tetracycline will result in the formation of a complex substance which is difficult to absorb.
Storage
Store below 30°C.
ATC Classification
A02BX02 - sucralfate ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Tab 500 mg x 10 x 10's. Oral susp 500 mg/5 mL x 100 mL x 1's.
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