Vaccine, tetanus toxoid, tetanus toxoid adsorbed: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Active immunisation against tetanus

Adult: Primary immunisation: 3 or 4 doses of 0.5 mL each, with dosing intervals depending on the product used. Booster dose: 0.5 mL every 10 years.
Child: Primary immunisation: ≥6-8 weeks Same as adult dose.

Intramuscular
Prophylaxis of tetanus in wound management

Adult: Non-immunised patients, or if >5-10 years since last booster dose: 1 emergency dose of 0.5 mL, depending on the type of wound. Patients with minor, clean wounds who have been vaccinated within the last 5-10 years may not need emergency booster dose.

Contraindications

Hypersensitivity. Neurological disorders following previous vaccination.

Special Precautions

Patient with coagulation/bleeding disorders (e.g. thrombocytopenia), Guillain-Barré syndrome (within 6 weeks prior to receiving vaccination), immunodeficiency (e.g. HIV infection). Patients with complete primary vaccination or a booster dose in the previous 5 years. Postpone vaccination in patients with acute febrile illness. Children. Pregnancy and lactation.

Adverse Reactions

Significant: Syncope.
Blood and lymphatic system disorders: Lymphadenopathy.
Gastrointestinal disorders: Nausea.
General disorders and administration site conditions: Inj site reactions (e.g. pain, redness, bruising, swelling, induration), fever, malaise, irritability.
Musculoskeletal and connective tissue disorders: Arthralgia, myalgia.
Nervous system disorders: Neuritis, headache, dizziness.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Hypotension.
Potentially Fatal: Anaphylactoid or hypersensitivity reactions.

Pregnancy Category (US FDA)

IM/Parenteral/SC: C

Monitoring Parameters

Monitor for syncope, hypersensitivity reactions, 15 minutes after administration.

Drug Interactions

Increased risk of bleeding with anticoagulants. Decreased therapeutic effect and immune response with immunosuppressive therapies (e.g. high-dose corticosteroids).

Action

Description: Tetanus toxoid vaccine is a preparation of inactivated toxin produced by virulent tetanus bacilli (product of Clostridium tetani). It acts as antigen and produces active immunity against tetanus.
Duration: Immunity: Approx 10 years.

Storage

Store between 2-8°C. Do not freeze. Protect from light.
Any unused portions should be disposed of in accordance with local requirements.

MIMS Class

Vaccines, Antisera & Immunologicals

ATC Classification

J07AM01 - tetanus toxoid ; Belongs to the class of tetanus bacterial vaccines.

References

Anon. Tetanus Toxoid (Adsorbed). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/08/2018.

Buckingham R (ed). Tetanus Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/08/2018.

Tetavax Multidose and Single Dose Tetanus Vaccine (Sanofi Pasteur). MIMS Singapore. http://www.mims.com/singapore. Accessed 20/08/2018.

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