Instructions for use, handling and disposal: The powder must be constituted with water for injections and the resulting constituted solution must then be immediately diluted prior to use. The constituted solution is a pale yellow solution that is free of any particles.
Standard aseptic techniques should be used for solution preparation and administration.
ZINFORO powder should be constituted with 20 ml sterile water for injections. The resulting constituted solution should be shaken prior to being transferred to an infusion bag or bottle containing one of the following diluents: sodium chloride 9 mg/ml (0.9 %) solution for injection; dextrose 50 mg/ml (5 %) solution for injection; sodium chloride 4.5 mg/ml and dextrose 25 mg/ml solution for injection (0.45% sodium chloride and 2.5% dextrose); Lactated Ringer's solution.
Routinely, a 250 ml infusion bag should be used to prepare the infusion and only in exceptional patients for whom there could be great concern over volumes infused should a 50 ml or 100 ml infusion bag be used. The total time interval between starting constitution and completing preparation of the intravenous infusion should not exceed 30 minutes.
One ml of the constituted solution contains 30 mg of ceftaroline fosamil.
For storage conditions of the constituted and diluted medicinal product, see Shelf life under Storage.
Each vial is for single use only.
Any unused product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: This medicinal product must not be mixed with other medicinal products except those mentioned in Instructions for use, handling and disposal as previously mentioned.