Zovirax Tablet

Zovirax Tablet Dosage/Direction for Use

aciclovir

Manufacturer:

GlaxoSmithKline Indonesia
Full Prescribing Info
Dosage/Direction for Use
Adults: Treatment of Herpes Simplex: 200 mg 5 times daily at approximately 4-hrly intervals omitting the nighttime dose. Treatment should continue for 5 days, but in severe infections, may have to be extended.
Severely Immunocompromised Patients (eg, after marrow transplant) or In Patients with Impaired Absorption from the Gut: Dose can be doubled to 400 mg or alternatively, IV dosing could be considered.
Dosing should begin as early as possible after the start of an infection. For recurrent episodes, this should preferably be during the prodromal period or when lesions first appeared.
Suppression of Herpes Simplex in Immunocompetent Adults:
200 mg 4 times daily at approximately 6-hrly intervals.
Many patients may be conveniently managed on a regimen of 400 mg twice daily at approximately 12-hrly intervals.
Dosage titration down to 200 mg 3 times daily at approximately 8-hrly intervals or even twice daily at approximately 12-hrly intervals, may prove effective.
Some patients may experience breakthrough infections on total daily doses of 800 mg.
Therapy should be interrupted periodically at intervals of 6-12 months in order to observe possible changes in the natural history of the disease.
Prophylaxis of Herpes Simplex in Immunocompromised Adults: 200 mg 4 times daily at approximately 6-hrly intervals.
Severe Immunocompromised Patients (eg, after marrow transplant) or In Patients with Impaired Absorption from the Gut: Dose can be doubled to 400 mg or alternatively, IV dosing could be considered.
The duration of prophylactic administration is determined by the duration of the period at risk.
Treatment of Varicella and Herpes Zoster in Adults: 800 mg 5 times daily at approximately 4-hrly intervals, omitting the nighttime dose. Treatment should continue for 7 days.
In severe immunocompromised patients (eg, after marrow transplant) or in patients with impaired absorption from the gut,consideration should be given to IV dosing.
Dosing should begin as early as possible after the start of an infection; treatment yields better results if initiated as soon as possible after onset of the rash.
Children: Treatment of Herpes Simplex Infections and Prophylaxis of Herpes Simplex Infections in Immunocompromised: ≥2 years: Same as adult dose, <2 years: ½ the adult dose should be given.
Treatment of Varicella Infection: Children >6 years: 800 mg 4 times daily, 2-6 years: 400 mg 4 times daily, <2 years: 200 mg 4 times daily. Dosing may be more accurately calculated as 20 mg/kg bodyweight not exceeding 800 mg 4 times daily.
Treatment should continue for 5 days.
No specific data are available on the suppression of herpes simplex infections or the treatment of herpes zoster infection in immunocompetent children.
Elderly: The possibility of renal impairment in the elderly must be considered and the dosage should be adjusted accordingly (see Renal Impairment as follows). Adequate hydration of elderly patients taking high oral doses of aciclovir should be maintained.
Renal Impairment: Caution is advised when administering Zovirax oral formulations to patients with impaired renal function. Adequate hydration should be maintained.
In the treatment and prophylaxis of herpes simplex infections in patients with impaired renal function, the recommended oral doses will not lead to accumulation of aciclovir above levels that have been established safe by IV infusion. However, for patients with severe renal impairment (creatinine clearance <10 mL/min), an adjustment of dosage to 200 mg twice daily at approximately 12-hrly intervals is recommended.
In the treatment of varicella and herpes zoster infections, it is recommended to adjust the dosage to 800 mg twice daily at approximately 12-hrly intervals for patients with severe renal impairment (creatinine clearance <10 mL/min) and to 800 mg 3 times daily at intervals of approximately 8 hrs for patients with moderate renal impairment (creatinine clearance in the range of 10-25 mL/min).
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