(See also Pharmacokinetics: Drug-Drug Interactions under Actions.)
Monoamine Oxidase Inhibition: Linezolid is a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents.
Adrenergic Agents: Some individuals receiving Zyvox may experience a reversible enhancement of the pressor response to indirect-acting sympathomimetic agents, vasopressor or dopaminergic agents. Commonly used drugs eg, phenylpropanolamine and pseudoephedrine have been specifically studied. Initial doses of adrenergic agents eg, dopamine or epinephrine, should be reduced and titrated to achieve the desired response.
Serotonergic Agents: Co-administration of linezolid and serotonergic agents was not associated with serotonin syndrome in phase 1, 2 or 3 studies. Spontaneous reports of serotonin syndrome occurring with co-administration of Zyvox and serotonergic agents have occurred. Physicians should be alert to the possibility of signs and symptoms of serotonin syndrome (hyperreflexia, incoordination, hyperpyrexia and cognitive dysfunction) in patients receiving concomitant serotonergic agents.
Drug-Laboratory Test: There are no reported drug-laboratory test interactions.