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In the event of overdosage, supportive care is advised, with maintenance of glomerular filtration. Hemodialysis may facilitate more rapid elimination of linezolid. In a phase 1 clinical trial, approximately 30% of a dose of linezolid was removed during a 3-hr hemodialysis session beginning 3 hrs after the dose of linezolid was administered. Data are not available for removal of linezolid with peritoneal dialysis or hemoperfusion. Clinical signs of acute toxicity in animals were decreased activity and ataxia in rats and vomiting and tremors in dogs treated with 3000 and 2000 mg/kg/day, respectively.