Weight loss makes no difference in older patients with overweight and persistent AF
29 May 2026
byJairia Dela Cruz
In older patients with overweight and persistent atrial fibrillation (AF) referred for direct current cardioversion, an 8-month structured dietary weight loss and behavioural support program leads to a significant reduction in weight without inducing functional decline. However, this metabolic benefit does not translate into improvements in AF outcomes, according to the LOSE-AF trial.