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Abilify Maintena

Abilify Maintena

aripiprazole

Manufacturer:

Lundbeck

Distributor:

Zuellig Pharma

Marketer:

Otsuka
Concise Prescribing Info
Contents
Aripiprazole
Indications/Uses
Maintenance treatment of schizophrenia & maintenance monotherapy treatment of bipolar I disorder in adult patients.
Dosage/Direction for Use
400 mg once mthly as single IM inj (no sooner than 26 days after previous inj).
Special Precautions
Hypersensitivity. Not to be inj IV or SC. Not indicated for dementia-related psychosis. Suicidal behaviour. Patients w/ known CV & cerebrovascular disease or other conditions predisposing to hypotension or HTN; venous thromboembolism. History of QT prolongation & seizures. Tardive dyskinesia; neuroleptic malignant syndrome; hyperglycemia & DM; wt gain; pathological gambling & impulse-control disorders; somnolence, postural hypotension, motor & sensory instability leading to falls, fractures & other injuries; orthostatic hypotension. Patients at risk for aspiration pneumonia. Avoid concomitant use w/ CYP3A4 inducers. Concomitant use w/ strong CYP2D6 &/or CYP3A4 inhibitors. May affect ability to drive & use machines. Severe hepatic impairment. Not to be used during pregnancy. Lactation. Childn & adolescents ≤17 yr. Elderly ≥65 yr.
Adverse Reactions
Increased/decreased wt, DM; agitation, anxiety, restlessness, insomnia; extrapyramidal disorder, akathisia, tremor, dyskinesia, sedation, somnolence, dizziness, headache; dry mouth; musculoskeletal stiffness; erectile dysfunction; inj site pain & induration, fatigue; increased blood creatine phosphokinase.
Drug Interactions
Enhanced effect of certain antihypertensives. Increased conc w/ quinidine or other CYP2D6 inhibitors. Increased AUC & Cmax w/ strong CYP3A4 inhibitors eg, ketoconazole, itraconazole, HIV PIs. Increased plasma conc w/ weak CYP3A4 (eg, diltiazem) or CYP2D6 (eg, escitalopram) inhibitors. Decreased Cmax & AUC w/ carbamazepine & other strong CYP3A4 inducers eg, rifampicin, rifabutin, phenytoin, phenobarb, primidone, efavirenz, nevirapine, St. John's wort. Serotonin syndrome w/ other serotonergic drugs eg, SSRI/SNRI or drugs increasing aripiprazole conc. Alcohol or other CNS drugs; drugs causing QT prolongation  or electrolyte imbalance.
MIMS Class
ATC Classification
N05AX12 - aripiprazole ; Belongs to the class of other antipsychotics.
Presentation/Packing
Form
Abilify Maintena PR susp for inj 400 mg
Packing/Price
1's
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