In combination w/ cisplatin
IV infusion over 10 min on 1st day of each 21-day cycle (cisplatin 75 mg/m2
infused over 2 hr approx 30 min after completion of pemetrexed infusion). Monotherapy
IV infusion over 10 min on 1st day of each 21-day cycle. Premed regimen
Oral dexamethasone 4 mg bd given the day prior to, on the day of & day after pemetrexed administration. Oral folic acid 350-1,000 mcg daily at least 5 doses during the 7 days preceding 1st dose of pemetrexed, continued during the full course of therapy & for 21 days after last dose of pemetrexed. IM vit B12
(1,000 mcg) in the wk preceding 1st dose of pemetrexed & once every 3 cycles thereafter.