Acetec

Acetec

enalapril

Manufacturer:

Biolab

Distributor:

Medispec
Concise Prescribing Info
Contents
Enalapril maleate
Indications/Uses
HTN. Adjunct to digitalis &/or diuretic therapy in CHF.
Dosage/Direction for Use
Essential HTN Initially 10-20 mg once daily. Individualized dosage. Usual maintenance dose: 20 mg once daily. Max: 40 mg daily. Heart failure &/or symptomatic left ventricular dysfunction Initially 2.5 mg. Individualized dosage. Usual maintenance dose: 20 mg in 1-2 divided doses over 2-4 wk. Mild renal impairment CrCl <80 to >30 mL/min 5-10 mg daily. Moderate renal impairment CrCl ≤30 to >10 mL/min 2.5-5 mg daily. Severe impairment eg, patient on dialysis CrCl ≤10 mL/min 2.5 mg on dialysis days.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Patients w/ history of angioneurotic edema w/ ACE inhibitor.
Special Precautions
Patients w/ CHF, vol depletion, ischemic heart or cerebrovascular disease, undergoing major surgery or during anesth. K supplement or K sparing diuretics. Reduce dosage &/or w/draw if increased BUN & creatinine conc occur. Neutropenia, thrombocytopenia, bone marrow depression & agranulocytosis have occurred rarely. Renal & hepatic impairment. Pregnancy & lactation. Childn.
Adverse Reactions
Hypotension w/ diuretics, dehydrated or under limited salt diet. Renal function disturbance eg, glycosuria, proteinuria or acute renal failure. Diaphoresis, erythema multiforme, exfoliative dermatitis, SJS, TEN, pemphigus, pruritus, urticaria, alopecia. Ileus, pancreatitis, hepatic failure, hepatitis (hepatocellular or cholestatic), jaundice, abdominal pain, vomiting, dyspepsia, constipation, anorexia, stomatitis. Increase in blood urea & serum creatinine & elevations of liver enzymes &/or serum bilirubin; hyperkalemia & hyponatremia; decrease in Hb & hematocrit. Hypersensitivity, angioneurotic edema of the face, extremities, lips, tongue, glottis &/or larynx. Pulmonary infiltrates, bronchospasm/asthma, dyspnea, rhinorrhea, sore throat & hoarseness. Depression, confusion, somnolence, insomnia, nervousness, paresthesia, vertigo.
Drug Interactions
Hypotensive effect enhanced by other antihypertensives. Hyperkalemia w/ K-sparing diuretics or K prep. Reduced lithium clearance. Increased plasma digoxin level. Hypersensitivity reaction w/ allopurinol. Decreased hypotensive effect w/ rifampin & indomethacin. Increased hypotensive effect w/ phenothiazine.
MIMS Class
ACE Inhibitors/Direct Renin Inhibitors
ATC Classification
C09AA02 - enalapril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Acetec tab 20 mg
Packing/Price
10 × 10's;3 × 10's
Form
Acetec tab 5 mg
Packing/Price
10 × 10's;3 × 10's
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