Acetec

Acetec

enalapril

Manufacturer:

Biolab

Distributor:

Medispec
Concise Prescribing Info
Contents
Enalapril maleate
Indications/Uses
HTN. Adjunct to digitalis &/or diuretic therapy in CHF.
Dosage/Direction for Use
Essential HTN Initially 10-20 mg once daily. Individualized dosage. Usual maintenance dose: 20 mg once daily. Max: 40 mg daily. Heart failure &/or symptomatic left ventricular dysfunction Initially 2.5 mg. Individualized dosage. Usual maintenance dose: 20 mg in 1-2 divided doses over 2-4 wk. Mild renal impairment CrCl <80 to >30 mL/min 5-10 mg daily. Moderate renal impairment CrCl ≤30 to >10 mL/min 2.5-5 mg daily. Severe impairment eg, patient on dialysis CrCl ≤10 mL/min 2.5 mg on dialysis days.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Patients w/ history of angioneurotic edema w/ ACE inhibitor.
Special Precautions
Patients w/ CHF, vol depletion, ischemic heart or cerebrovascular disease, undergoing major surgery or during anesth. K supplement or K sparing diuretics. Reduce dosage &/or w/draw if increased BUN & creatinine conc occur. Neutropenia, thrombocytopenia, bone marrow depression & agranulocytosis have occurred rarely. Renal & hepatic impairment. Pregnancy & lactation. Childn.
Adverse Reactions
Hypotension w/ diuretics, dehydrated or under limited salt diet. Renal function disturbance eg, glycosuria, proteinuria or acute renal failure. Diaphoresis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, pemphigus, pruritus, urticaria, alopecia. Ileus, pancreatitis, hepatic failure, hepatitis (hepatocellular or cholestatic), jaundice, abdominal pain, vomiting, dyspepsia, constipation, anorexia, stomatitis. Increase in blood urea & serum creatinine & elevations of liver enzymes &/or serum bilirubin; hyperkalemia & hyponatremia; decrease in Hb & hematocrit. Hypersensitivity, angioneurotic edema of the face, extremities, lips, tongue, glottis &/or larynx. Pulmonary infiltrates, bronchospasm/asthma, dyspnea, rhinorrhea, sore throat & hoarseness. Depression, confusion, somnolence, insomnia, nervousness, paresthesia, vertigo.
Drug Interactions
Hypotensive effect enhanced by other antihypertensives. Hyperkalemia w/ K-sparing diuretics or K prep. Reduced lithium clearance. Increased plasma digoxin level. Hypersensitivity reaction w/ allopurinol. Decreased hypotensive effect w/ rifampin & indomethacin. Increased hypotensive effect w/ phenothiazine.
ATC Classification
C09AA02 - enalapril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Acetec tab 20 mg
Packing/Price
10 × 10's;3 × 10's
Form
Acetec tab 5 mg
Packing/Price
10 × 10's;3 × 10's
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