Actos

Actos

pioglitazone

Manufacturer:

Takeda

Distributor:

DKSH
Concise Prescribing Info
Contents
Pioglitazone HCl
Indications/Uses
Monotherapy for type 2 DM patients particularly overwt patients, inadequately controlled by diet & exercise for whom metformin is inappropriate because of CI or intolerance. In combination w/ metformin or sulfonylurea for type 2 DM patients w/ insufficient glycaemic control.
Dosage/Direction for Use
Adult Monotherapy Initially 15 or 30 mg once daily, may be increased in increments up to 45 mg once daily. Combination therapy Current metformin or sulfonylurea dose can be continued upon initiation of pioglitazone therapy.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Cardiac failure (NYHA I-IV); diabetic ketoacidosis, current or history of bladder cancer, uninvestigated macroscopic haematuria. Hepatic impairment.
Special Precautions
Not to be used in type 1 diabetes or diabetic ketoacidosis. Heart failure, wt gain, oedema, reduced cardiac reserve; hypoglycaemia; new-onset or worsening diabetic macular oedema w/ decreased visual acuity. Increased incidence of bone fractures in women. Assess risk factors for bladder cancer prior to treatment. Monitor liver enzymes prior to & periodically thereafter. Concomitant use w/ NSAIDs including selective COX-2 inhibitors, gemfibrozil or rifampicin. Strict calorie-controlled diet. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Not to be used in hepatic impairment & dialysed patients. Resumption of ovulation in patients w/ polycystic ovarian syndrome. Not to be used during pregnancy & lactation. Not recommended in childn & adolescents <18 yr. Elderly.
Adverse Reactions
Upper resp tract infection; hypoaesthesia; bone fracture; increased wt; visual disturbance. W/ metformin: Anaemia; headache; arthralgia; haematuria; erectile dysfunction. W/ sulfonylurea: Dizziness; flatulence
Drug Interactions
Increased AUC w/ gemfibrozil. Decreased AUC w/ rifampicin.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BG03 - pioglitazone ; Belongs to the class of thiazolidinediones. Used in the treatment of diabetes.
Presentation/Packing
Form
Actos tab 15 mg
Packing/Price
10's;30's
Form
Actos tab 30 mg
Packing/Price
10's;30's
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