Not to be used in type 1 diabetes or diabetic ketoacidosis. Heart failure, wt gain, oedema, reduced cardiac reserve; hypoglycaemia; new-onset or worsening diabetic macular oedema w/ decreased visual acuity. Increased incidence of bone fractures in women. Assess risk factors for bladder cancer prior to treatment. Monitor liver enzymes prior to & periodically thereafter. Concomitant use w/ NSAIDs including selective COX-2 inhibitors, gemfibrozil or rifampicin. Strict calorie-controlled diet. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Not to be used in hepatic impairment & dialysed patients. Resumption of ovulation in patients w/ polycystic ovarian syndrome. Not to be used during pregnancy & lactation. Not recommended in childn & adolescents <18 yr. Elderly.