Recommended Dose: The immunization schedule with ADACEL should follow local recommendations.
ADACEL (0.5 ml) should be administered as a booster dose by the intramuscular route.
ADACEL may be administered to pregnant women during the second or third trimester to provide passive protection of infants against pertussis (see INDICATIONS/USES and Use in Pregnancy under PRECAUTIONS).
Re-dosing with ADACEL can be used to boost immunity to diphtheria, tetanus and pertussis at 5- to 10-year intervals in adolescents and adults.
The preferred site is into the deltoid muscle.
Fractional doses (doses <0.5 mL) should not be given. The effect of fractional doses on the safety and efficacy has not been determined.
The use of ADACEL in management of tetanus-prone wounds should follow local recommendations. (See Table 2.)
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Administration: Inspect for extraneous particulate matter and/or discolouration before use. (See DESCRIPTION.) If these conditions exist, the product should not be administered.
Shake the vial well until a uniform, cloudy, suspension results. Cleanse the vial stopper with a suitable germicide prior to withdrawing the dose. Do not remove either the stopper or the metal seal holding it in place. Aseptic technique must be used. Use a separate sterile needle and syringe, or a sterile disposable unit for each individual recipient, to prevent disease transmission. Needles should not be recapped but should be disposed of according to biohazard waste guidelines. (See PRECAUTIONS.)
Before injection, the skin over the site to be injected should be cleansed with a suitable germicide. Administer the total volume of 0.5 mL intramuscularly (IM). The preferred site of injection is the deltoid muscle.