Adalat LA

Adalat LA





Zuellig Pharma
Concise Prescribing Info
CHD: Chronic stable angina pectoris; HTN.
Dosage/Direction for Use
Initially 1 tab once daily, may be increased in increments up to 120 mg once daily.
May be taken with or without food: Swallow whole, do not chew/break tab. Avoid grapefruit juice.
Hypersensitivity. CV shock, patients w/ Kock pouch. Combination w/ rifampicin. Pregnancy before wk 20 & lactation.
Special Precautions
Patients w/ very low BP, manifest heart failure, severe aortic stenosis; preexisting severe GI narrowing; history of GI disorders. Regularly monitor BP especially when used w/ IV Mg sulfate. May affect ability to drive & use machines. Avoid concomitant use w/ grapefruit juice. Co-administration w/ CYP3A4 inhibitors or inducers. False +ve effects w/ barium contrast X-ray. Hepatic impairment. Pregnancy after wk 20. Childn <18 yr.
Adverse Reactions
Headache; oedema, vasodilatation; constipation; feeling unwell.
Drug Interactions
Altered clearance w/ CYP450 inhibitors or inducers. Weakened efficacy by rifampicin; anti-epileptic drugs eg, phenytoin, carbamazepine, phenobarb. Increased plasma conc w/ macrolides eg, erythromycin; anti-HIV PIs eg, ritonavir; azole anti-mycotics eg, ketoconazole; fluoxetine, nefazodone, quinupristin/dalfopristin, valproic acid, cimetidine, cisapride; grapefruit juice. Increased BP-lowering effect of diuretics, β-blockers, ACE inhibitors, angiotensin II receptor antagonists, other Ca antagonists, α-adrenergic blocking agents, PDE5 inhibitors, α-methyldopa. Increased digoxin, quinidine plasma conc. Monitor tacrolimus conc. Falsely increased urinary vanillylmandelic acid spectrophotometric values.
MIMS Class
Calcium Antagonists / Anti-Anginal Drugs
ATC Classification
C08CA05 - nifedipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Adalat LA PR tab 30 mg
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