Discontinue use if allergic or anaphylactic-type reactions occur. Hypervolaemia or haemodilution eg, decompensated cardiac insufficiency, HTN, oesophageal varices, pulmonary oedema, haemorrhagic diathesis, severe anaemia, renal & post-renal anuria; severe traumatic brain injury. Discontinue use at 1st clinical sign of CV overload or increased BP, venous pressure & pulmonary oedema. Patients on controlled Na or K diet. Monitor patient's electrolyte status. Ensure adequate substitution of other blood constituent in large vol replacement eg, coagulation factors, electrolytes, platelets & erythrocytes. Reduced kidney function. Childn. 20%: Ensure adequate hydration & monitor patients against circulatory overload & hyperhydration.