Alkeran

Alkeran

melphalan

Manufacturer:

Aspen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Melphalan
Indications/Uses
Tab: Multiple myeloma, advanced ovarian adenocarcinoma, breast carcinoma, polycythaemia rubra vera. Inj: Localised malignant melanoma & soft tissue sarcoma of the extremities; multiple myeloma, advanced ovarian adenocarcinoma, advanced neuroblastoma in childhood.
Dosage/Direction for Use
Tab Multiple myeloma 0.15 mg/kg daily in divided doses for 4 days repeated at 6-wk intervals. Advanced ovarian adenocarcinoma 0.2 mg/kg daily for 5 days every 4-8 wk. Breast carcinoma 0.15 mg/kg or 6 mg/m2 daily for 5 days & repeated every 6 wk. Polycythaemia rubra vera Remission induction: 6-10 mg daily for 5-7 days, then 2-4 mg daily until satisfactory disease control is achieved. Maintenance: 2-6 mg once wkly. Inj Multiple myeloma Intermittent basis alone or in combination w/ other cytotoxic drugs: 8-30 mg/m2 given at 2-6 wk intervals. Monotherapy: 0.4 mg/kg IV repeated at appropriate intervals. Advanced ovarian adenocarcinoma Monotherapy: 1 mg/kg given at 4-wk intervals. Combination therapy: 0.3-0.4 mg/kg given at 4-6 wk intervals. Advanced neuroblastoma in childhood 100-240 mg/m2 together w/ hematopoietic stem cell rescue, alone or in combination w/ radiotherapy &/or other cytotoxic drugs.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals. Swallow whole, do not break/crush.
Contraindications
Lactation.
Special Precautions
Monitor blood counts. Patients who have recently received radiotherapy or other cytotoxic agents. Moderate to severe renal impairment. Pregnancy. Childn.
Adverse Reactions
Bone marrow depression; nausea, vomiting, diarrhoea; stomatitis & alopecia (high doses); temporary significant elevations of blood urea. Inj: Muscle atrophy, muscle fibrosis, myalgia, increased blood creatinine phosphokinase, compartment syndrome; subjective & transient warm &/or tingling sensation.
Drug Interactions
Nalidixic acid, cyclosporin; live vaccines.
ATC Classification
L01AA03 - melphalan ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Alkeran tab 5 mg
Packing/Price
25's
Form
Alkeran tab 2 mg
Packing/Price
25's
Form
Alkeran inj 50 mg
Packing/Price
1's
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