Not to be given in patients w/ esophageal abnormalities or other factors that may delay esophageal emptying, those unable to stand or sit upright for at least 30 min. History of upper GI disease (eg, dysphagia, esophageal diseases, gastritis, duodenitis, ulcers). Correct hypocalcemia before starting therapy. Ensure adequate hydration. Not recommended in severe renal impairment (CrCl <35 mL/min). Not to be used during pregnancy & lactation.