Taiwan Biotech


SS Health
Concise Prescribing Info
Short-term treatment of moderate or severe anxiety & anxiety associated w/ depression.
Dosage/Direction for Use
Anxiety 0.25 mg-0.5 mg tds, may be increased to 3 mg daily. Geriatric & debilitated patient 0.25 mg bd-tds. Duration: Not >8-12 wk.
May be taken with or without food: Side effects (eg, sleepiness/drowsiness) may be reduced if taken immediately after meals.
Hypersensitivity to benzodiazepines. Myasthenia gravis, severe resp & hepatic insufficiency, sleep apnoea syndrome.
Special Precautions
Anaphylaxis & angioedema. Not to be used for short-term mild anxiety. Not recommended for the primary treatment of psychotic illness. History of alcohol or drug abuse. Severely depressed or suicidal patients. Tolerance, dependence; rebound insomnia & anxiety; amnesia; psychiatric & paradoxical reactions. Complex sleep-related behaviors. Chronic resp insufficiency. Avoid abrupt discontinuation of treatment. Long-term use. Concomitant use w/ opioids. May impair ability to drive & use machines. Renal or hepatic impairment. Women of childbearing potential. Avoid using in pregnancy. Not to be used during lactation. Not recommended in childn. Elderly.
Adverse Reactions
Sedation/drowsiness, lightheadedness, numbed emotions, reduced alertness, confusion, fatigue, headache, dizziness, muscle weakness, ataxia, double or blurred vision, insomnia, nervousness/anxiety, tremor, wt change, GI disturbances, changes in libido, skin reactions. Amnesia, depression, psychiatric & paradoxical reactions, dependence.
Drug Interactions
Increased risk of resp depression, profound sedation, coma & death w/ opioids. Enhanced sedative effect w/ alcohol. Enhanced central depressive effect w/ antipsychotics, hypnotics, anxiolytics/sedatives, antidepressants, narcotic analgesics, antiepileptics, anaesth & sedative antihistamines. Ketoconazole, itraconazole, other azole-type antifungals; nefazodone, fluvoxamine, cimetidine; fluoxetine, propoxyphene, OCs, sertraline, diltiazem, macrolides; ritonavir.
MIMS Class
ATC Classification
N05BA12 - alprazolam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Alpraline tab 0.5 mg
10 × 10's
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