Generic Medicine Info
Indications and Dosage
Gastrointestinal tract spasm
Adult: For the relief of smooth muscle spasms in conditions such as irritable bowel syndrome and diverticular disease of the colon: 60-120 mg 1-3 times daily. Consult the doctor if your symptoms worsen or do not improve after 2 weeks of treatment, or if you develop new symptoms.
Child: ≥12 years Same as adult dose.

Primary dysmenorrhoea
Adult: 60-120 mg 1-3 times daily. Consult the doctor if your symptoms worsen or do not improve after 2 weeks of treatment, or if you develop new symptoms.
Child: ≥12 years Same as adult dose.
Paralytic ileus, intestinal obstruction.
Special Precautions
Patient with nausea or vomiting, anorexia, weight loss, pallor, fatigue, fever, blood from the bowel, severe constipation, dysuria, and abnormal vaginal discharge or bleeding. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Jaundice (reversible); abnormal LFTs.
Gastrointestinal disorders: Nausea.
Hepatobiliary disorders: Hepatitis (reversible).
Immune system disorders: Hypersensitivity reaction, anaphylaxis.
Nervous system disorders: Headache, dizziness.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, wheezing.
Skin and subcutaneous tissue disorders: Rash, pruritus.
Patient Counseling Information
This drug may cause dizziness, if affected, do not drive or operate machinery.
Symptoms: Atropine-like effects and hypotension. Management: Supportive treatment for hypotension. Manage atropine-like effects as for atropine poisoning.
Description: Alverine is an antispasmodic agent that directly acts on the intestinal and uterine smooth muscles, without affecting the heart, blood vessels and tracheal muscles.
Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-1.5 hours (PHA).
Metabolism: Rapidly metabolised into para hydroxy alverine (PHA), primary active metabolite; undergoes further conversion to form 2 secondary metabolites.
Excretion: Via urine (as metabolites). Elimination half-life: 0.8 hours (alverine); 5.7 hours (PHA).
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Alverine, CID=3678, (accessed on Jan. 20, 2020)

Store below 25°C. Protect from moisture.
MIMS Class
ATC Classification
A03AX08 - alverine ; Belongs to the class of other drugs used for functional bowel disorders.
Alverine Citrate 60 mg Hard Capsules (Morningside Healthcare Ltd). MHRA. Accessed 06/05/2021.

Anon. Alverine Citrate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 06/05/2021.

Buckingham R (ed). Alverine Citrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 06/05/2021.

Joint Formulary Committee. Alverine Citrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 06/05/2021.

Spasmonal Forte 120 mg, Hard Capsules (Mylan Products Ltd.). MHRA. Accessed 06/05/2021.

Disclaimer: This information is independently developed by MIMS based on Alverine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in