In general, treatment with Amlodipine besilate was well-tolerated at doses up to 10 mg daily. Most adverse reactions reported during therapy with Amlodipine besilate were of mild or moderate severity. The most common side effects are headache and edema.
Cardiovascular: Arrhythmia (including ventricular tachycardia and atrial fibrillation), bradycardia, chest pain, hypotension, peripheral ischemia, syncope, tachycardia, postural dizziness, postural hypotension.
Central and Peripheral Nervous System: hypoesthesia, paresthesia, tremor, vertigo.
Gastrointestinal: anorexia, constipation, dyspepsia, dysphagia, diarrhea, flatulence, vomiting, gingival hyperplasia.
General: Asthenia, back pain, hot flushes, malaise, pain, rigors, weight gain.
Musculoskeletal System: Arthralgia, arthrosis, muscle cramps, myalgia.
Psychiatric: sexual dysfunction (male and female), insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization.
Respiratory System: Dyspnea, epistaxis.
Skin and Appendages: Pruritus, rash, rash erythematous, rash maculopapular.