Amdepin Dosage/Direction for Use



Cadila Pharma


Pahang Pharmacy
Full Prescribing Info
Dosage/Direction for Use
Adults: For both hypertension and angina, the recommended initial dose is 5 mg. Amdepin orally once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
The dose does not need adjusting when Amdepin is given concurrently with thiazide diuretics, beta-adrenoceptor blocking agents or angiotensin converting enzyme inhibitors. Amdepin can be administered with or without food.
Children: Since there is no clinical experience in patients of less than 18 years, use in children is not currently recommended.
Elderly: Although elderly patients may have higher plasma concentrations of amlodipine than younger patients, the terminal elimination half-lives are similar. Amdepin is similarly well tolerated elderly or younger patients. Therefore the normal dosage is recommended.
Renal Impairment: Amlodipine is extensively metabolised to inactive metabolites with 10% excreted as unchanged drug in the urine. Changes in amlodipine plasma concentration are not correlated with the degree of renal impairment, therefore the normal dosage is recommended. Amlodipine is not dialysable.
Patients with Impaired Hepatic Function: The half-life of amlodipine is prolonged in patients with impaired liver function and dosage recommendations have not been established. Amdepin should therefore be administered with caution in these patients.
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