Amdepin has been safely administered with thiazide diuretics, beta-adrenoceptor blocking drugs, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory drugs, antibiotics and oral hypoglycemic agents.
Co-administration of Amdepin with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers. Co-administration of cimetidine did not alter the pharmacokinetics of amlodipine.
In healthy volunteers, co-administration of Amdepin did not significantly alter the effect of warfarin on prothrombin time. The introduction of Amdepin is not likely to result in the need for modification of an established warfarin regimen.
In vitro data from studies with human plasma indicate that amlodipine has no effect on protein binding of digoxin, phenytoin, warfarin or indomethacin.