The most commonly observed side effects were headache, oedema, fatigue, somnolence, nausea, flushing, palpitations and dizziness. Vomiting and abdominal pain have occurred. Less commonly observed side effects include alopecia, altered bowel habits, arthralgia, asthenia, back pain, dyspepsia, dyspnea, gingival hyperplasia, gynecomastia, hyperglycemia, impotence, increased urinary frequency, leucopenia, malaise, mood changes and depression, dry mouth, muscle cramps, myalgia, peripheral neuropathy, pancreatitis, increased sweating, syncope, thrombocytopenia, vasculitis and visual disturbances. Allergic reactions including pruritus, rash, angioedema and erythema multiforme have also been observed. The following adverse events have been reported but cannot be distinguished from the natural history of the underlying disease; myocardial infarction, arrythmia (including ventricular tachycardia and atrial fibrillation) and chest pain. Hepatitis and jaundice and hepatic enzyme elevations have been reported (mostly consistent with cholestasis). Some cases severe enough to require hospitalisation have been reported in association with use of amlodipine.