Increased BP-lowering effects w/ grapefruit or grapefruit juice. Increased exposure to simvastatin. Increased risk of hypotension w/ strong or moderate CYP3A4 inhibitors eg, PIs, azole antifungals, macrolides (ie, erythromycin, clarithromycin), verapamil, diltiazem. Varied plasma conc w/ strong CYP3A4 inducers eg, rifampicin, Hypericum perforatum
. Increased tacrolimus blood levels. Increased trough conc of cyclosporin.