Concise Prescribing Info
Amlodipine besylate
1st-line treatment of HTN, myocardial ischemia whether due to fixed obstruction (stable angina) &/or vasospasm/vasoconstriction (Prinzmetal's or variant angina) of coronary vasculature.
Dosage/Direction for Use
Initially 5 mg once daily, may be increased to max: 10 mg.
May be taken with or without food: Swallow whole w/ water.
Hypersensitivity to amlodipine or dihydropyridines.
Special Precautions
CHF. May affect ability to drive & use machines. Hepatic impairment. Pregnancy & lactation. Childn.
Adverse Reactions
Headache, dizziness, somnolence; palpitations; flushing; abdominal pain, nausea; edema, fatigue.
Drug Interactions
Increased BP-lowering effects w/ grapefruit or grapefruit juice. Increased exposure to simvastatin. Increased risk of hypotension w/ strong or moderate CYP3A4 inhibitors eg, PIs, azole antifungals, macrolides (ie, erythromycin, clarithromycin), verapamil, diltiazem. Varied plasma conc w/ strong CYP3A4 inducers eg, rifampicin, Hypericum perforatum. Increased tacrolimus blood levels. Increased trough conc of cyclosporin.
MIMS Class
Calcium Antagonists / Anti-Anginal Drugs
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Amnoz tab 10 mg
10 × 10's
Amnoz tab 5 mg
10 × 10's
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