Amoxicillin + clavulanic acid - intravenous

Patient Medicine Information
Why do I need this medicine?
Amoxicillin and Clavulanic acid are combined in this medicine.

This medicine is an antibiotic. It is used to treat certain bacterial infections of the ears, nose, dental areas, throat, lungs, abdomen, bladder, female genitals, skin, bones and joints.

Amoxicillin + Clavulanic acid may also be used to prevent infections associated with major surgical procedures.
How do I use this medicine?
Amoxicillin + Clavulanic acid injection is to be given intravenously (into the vein) as a slow injection or an infusion. It is delivered directly into the bloodstream via the blood vessel.

The doctor, pharmacist or nurse will reconstitute your medicine. It should be used within 20 minutes of reconstitution.

Your doctor or nurse will administer the injection for you.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your infection.

Amoxicillin + Clavulanic acid injection must be administered at regular intervals. Do not skip any doses. You must complete the entire course of this medicine. If you don't, the infection will not be properly controlled.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Amoxicillin + Clavulanic acid.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Do not use this medicine if you had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to Amoxicillin or Clavulanic acid and other similar antibiotics such as penicillins (e.g. ampicillin, cloxacillin, sultamicillin), cephalosporins (e.g. cefaclor, cefalexin, cefuroxime), monobactam or carbapenem antibiotics.

Alert your doctor if you have a history of liver disease associated with Amoxicillin + Clavulanic acid, as this medicine may not be suitable for you.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • glandular fever (a type of viral infection also known as infectious mononucleosis)
  • unable to pass urine regularly
  • atopy (tendency to develop allergic reactions)
  • liver disease
  • kidney disease and those undergoing haemodialysis
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving this medicine to a child.

Maintain adequate fluid intake while you are being treated with Amoxicillin + Clavulanic acid.

If you are going for certain laboratory tests (e.g. urine glucose tests, Coombs’ test, Aspergillus EIA test), inform your doctor that you are being administered with this medicine.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine tests (e.g. complete blood count, liver and kidney function tests) may be done while you are being treated with this medicine. Your doctor will advise you about how often you will need to have these tests.
  • Regular monitoring for signs of infection (e.g. fever, sore throat) and allergic reactions (e.g. rash, swollen face or throat) may also be needed.
What side effects could I experience?
Amoxicillin + Clavulanic acid may cause any of the following side effects: diarrhoea, nausea, vomiting, indigestion, headache, skin rash or itching, and thrush in the mouth, skin folds or vagina.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swollen eyes, face or mouth
  • severe, persistent watery or bloody diarrhoea accompanied by stomach pain or fever
  • fits or seizures
  • difficulty to pass urine caused by the formation of crystals in urine
  • yellowing of the skin or eyes, abdominal pain, dark-coloured urine, unusual tiredness
  • unusual bleeding or bruising, frequent and persistent sore throat with fever
  • rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for gout (abnormal metabolism of uric acid) e.g. probenecid, allopurinol
  • blood-thinning medicines e.g. warfarin, acenocoumarol
  • mycophenolate mofetil (medicine used in organ transplant)
  • methotrexate (medicine for cancer)
  • birth control pills
This list does not include all medicines that may interact with Amoxicillin + Clavulanic acid.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Keep this medicine away from the reach of children.

Available products of Amoxicillin + Clavulanic acid may vary with its storage requirements. Ask your doctor or pharmacist on how to properly store this medicine.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on amoxicillin + clavulanic acid - intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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