Aricept Evess

Aricept Evess

donepezil

Manufacturer:

Eisai

Distributor:

DKSH
Concise Prescribing Info
Contents
Donepezil HCl
Indications/Uses
Mild, moderate & severe Alzheimer's dementia.
Dosage/Direction for Use
Adult & elderly Mild to moderate Alzheimer's disease 5 mg once daily at bedtime, may be increased to max: 10 mg once daily following 1 mth of clinical assessment. Severe Alzheimer's disease 10 mg once daily.
Administration
May be taken with or without food: Take at bedtime. Place tab on the tongue & allow to disintegrate before swallowing w/ or w/o water.
Contraindications
Hypersensitivity to donepezil HCl, piperidine derivatives.
Special Precautions
Neuroleptic malignant syndrome. Sick sinus syndrome or other supraventricular cardiac conduction conditions eg, SA or AV block; syncope or seizures; bladder outflow obstruction. History of ulcer disease, asthma or obstructive pulmonary disease. May exacerbate/induce extrapyramidal symptoms. Concomitant use w/ succinylcholine-type anesth. Concurrent use w/ NSAIDs. Avoid use w/ inhibitors of acetylcholinesterase agonists or cholinergic system antagonists. May affect ability to drive & use machines. Severe hepatic impairment. Not to be used during pregnancy & lactation. Not recommended in childn.
Adverse Reactions
Diarrhoea, nausea; headache. Common colds; anorexia; hallucinations, agitation, aggressive behaviour, abnormal dreams & nightmares; syncope, dizziness, insomnia; vomiting, abdominal disturbance; rash, pruritus; muscle cramps; urinary incontinence; fatigue, pain; accident.
Drug Interactions
Inhibited metabolism by ketoconazole, quinidine, itraconazole, erythromycin, fluoxetine. Reduced levels by rifampicin, phenytoin, carbamazepine, alcohol. Interfered w/ medications having anticholinergic activity. Synergistic activity w/ succinylcholine, other neuromuscular blockers or cholinergic agonists, β-blockers.
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Presentation/Packing
Form
Aricept Evess orodispersible tab 10 mg
Packing/Price
28's
Form
Aricept Evess orodispersible tab 5 mg
Packing/Price
28's
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