Atroxene Flex

Atroxene Flex

olive oil




Full Prescribing Info
Ozonized olive oil.
Contains ozonized olive oil which helps to reduce pain in knees, back, shoulder, other joints and muscles.
Pharmacology: Mode of Action: Mimics inhibition of COX-2 by reducing the prostaglandin productions.
Introduction: Pain is defined by International Association for Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or describe in terms of such damage".
The World Health Organization (WHO): 80% has either insufficient or no access to treatment for moderate to severe pain. Every year, 10 millions of people around the world suffer from such pain without treatment.
NSAIDs-frequently prescribed medicines for analgesia in primary care, after Paracetamol. The main therapeutic activity of each drug is accompanied by secondary effects, some of which have serious unwanted side effects.
Clinical Evidence: Ozonized of olive oil and methyl oleate inhibit the expression of cyclooxygenase-2 (COX-2) through the suppression of IxB/NFxB- dependent pathway in lipopolysaccharide- stimulated macrophages-like THP-1 cells.
Results: It was demonstrated that ozonized olive oil significantly inhibits the overproduction of PGE2 as well as COX-2 expression by inactivation of NFxB.
Efficacy and safety of Atroxene topical emulgel not containing synthetic ingredient as anti-inflammatory drug (NSAIDs), for the treatment of painful, acute and chronic pathologies of the musculoskeletal system.
Observational study on 326 patients to evaluate the antalgic, anti-inflammatory and safety action of Atroxene Flex.
Results: Atroxene shows significant results in both acute and chronic pathologies. No cutaneous intolerance has been highlighted. (See Table 1 and Table 2.)

Click on icon to see table/diagram/image

Click on icon to see table/diagram/image
Reduces inflammation, reduces pain.
Topical Emulgel, is a powerful anti-inflammatory therefore, a painkiller.
Can be used as a combination therapy with Oral COX-2 Inhibitors.
Can be used as a first line treatment for joint and muscle pain.
Suitable for patients who are prone to heart complications.
Can be used as a combination therapy with Oral NSAIDS.
Dosage/Direction for Use
Apply 1 to 2 inches gel on affected areas. Massage until absorbed.
No significant results.
Special Precautions
No significant results.
Adverse Reactions
According to National Pharmaceutical Regulatory Agency (NPRA), Malaysia had stated 1,575 Adverse Drug Reaction (ADR) cases were reported in year 2017 involving 14 types of NSAIDs such as: Skin and subcutaneous tissue disorders: 48%, Eye disorders: 29%, Respiratory, thoracic and mediastinal disorders: 10%, Systemic and local administration site reactions: 7%, Gastrointestinal disorders: 6%.
Side Effects
No significant results.
ATC Classification
M09AX - Other drugs for disorders of the musculo-skeletal system ; Used in the treatment of musculo-skeletal disorders.
Emulgel 100 mL.
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