As with other parenteral antibiotics, the principal side effect observed is injection site pain, especially associated with the intramuscular route of administration. A small number of patients may develop phlebitis or an injection-site reaction after intravenous administration.
Blood and Lymphatic System Disorders: anemia, hemolytic anemia, thrombocytopenia, eosinophilia and leucopenia have been reported during therapy with sulbactam sodium/ampicillin sodium. These reactions are reversible on discontinuation of therapy and are believed to be sensitivity reactions.
Gastrointestinal disorder: nausea, vomiting, diarrhea, enterocolitis and pseudomembranous colitis.
Hepatobiliary disorder: bilirubinemia, abnormal hepatic function and jaundice.
Immune System Disorders: Anaphylactoid reaction and anaphylactic shock.
Investigations: Transient elevations of ALT(SGPT) and AST(SGOT) transaminases.
Nervous System Disorders: rare reports of convulsions.
Renal and Urinary Disorder: rare reports of interstitial nephritis.
Skin and Subcutaneous tissue Disorders: rash, itching, other skin reactions, rare reports of Stevens-Johnson syndrome, epidermal necrolysis and erythema multi forme.
Adverse reactions associated with the use of ampicillin alone may be observed with sulbactam sodium/ampicillin sodium IM/IV.