Auropennz

Auropennz

ampicillin + sulbactam

Manufacturer:

Aurobindo Pharma

Distributor:

Unimed
Concise Prescribing Info
Contents
Per 1.5 g powd for inj Ampicillin Na 1,000 mg, sulbactam Na 500 mg. Per 3 g powd for inj Ampicillin Na 2,000 mg, sulbactam Na 1,000 mg
Indications/Uses
Upper & lower resp tract infections eg, sinusitis, otitis media, epiglottitis; bacterial pneumonia; UTI, pyelonephritis; intra-abdominal infections eg, peritonitis, cholecystitis, endometritis, pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone, joint & gonococcal infections. Peri-op reduction of post-op wound infection in patients undergoing abdominal or pelvic surgery. Reduce post-op sepsis in termination of pregnancy or cesarean section.
Dosage/Direction for Use
Adult 1.5-12 g daily in divided doses every 6 or 8 hr up to max: Sulbactam 4 g daily. Less severe infections May be treated every 12 hr. Prophylaxis of surgical infections 1.5-3 g at anesth induction, may be repeated every 6-8 hr. Uncomplicated gonorrhea 1.5 g as single dose. Childn, infant & neonate 150 mg/kg daily every 6-8 hr. Neonate 1st wk of life 75 mg/kg daily in divided doses every 12 hr.
Contraindications
Special Precautions
Hypersensitivity to penicillins & cephalosporins. Discontinue use if superinfection occurs. Not to be used in infectious mononucleosis. Clostridium difficile-associated diarrhea. Periodically check for organ system dysfunction during prolonged use. Pregnancy & lactation.
Adverse Reactions
Inj site pain; anemia, hemolytic anemia, thrombocytopenia, eosinophilia, leucopenia; nausea, vomiting, diarrhea, enterocolitis, pseudomembranous colitis; bilirubinemia, abnormal hepatic function, jaundice; anaphylactoid reaction & shock; transient elevations of ALT & AST transaminases; rash, itching, other skin reactions.
Drug Interactions
Increased incidence of rashes w/ allopurinol. Substantial mutual inactivation w/ aminoglycosides. Additive effects w/ anticoagulants. Interfered bactericidal effects by bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides, tetracyclines. Reduced effectiveness of estrogen-containing OCs. Decreased clearance & toxicity of methotrexate. Decreased renal tubular secretion by probenecid. False positive glycosuria test. In vitro inactivation w/ aminoglycosides.
MIMS Class
ATC Classification
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Auropennz powd for inj 1.5 g
Packing/Price
30 mL x 1's
Form
Auropennz powd for inj 3 g
Packing/Price
30 mL x 1's
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