Pharmacology: Pharmacodynamics: Micronized purified flavonoid fraction is a venotonic and vascular protector. It exerts an action on the vascular return system by reducing the venous distensibility and stasis (at the venous level) and normalises capillary permeability and increases capillary resistance (at the microcirculatory level).
Pharmacokinetics: Diosmin is synthesized from Hesperidin. Diosmin is highly metabolized and the elimination half-life is 11 hours. The excretion of Diosmin is mainly faecal, and about 14% of the dose administered is excreted in the urine.