OA 7.5 mg daily, may be increased to 15 mg daily. RA 15 mg daily, may be reduced to 7.5 mg daily. Ankylosing spondylitis 15 mg daily. Patient w/ increased risks of AR Initially 7.5 mg daily. Long-term treatment of RA in elderly 7.5 mg daily. Dialysis patient w/ severe renal failure Not to exceed 7.5 mg daily. Total daily dosage: Not to exceed 15 mg.
May be taken with or without food: May be taken w/ meals if GI discomfort occurs.
Hypersensitivity to aspirin & other NSAIDs. Not to be given in patients who develop signs of asthma, nasal polyps, angioneurotic oedema or urticaria. Severe heart failure. Active or history of recurrent peptic ulcer/haemorrhage; history of GI bleeding or perforation related to previous NSAIDs therapy; cerebrovascular bleeding or other bleeding disorders. Severe hepatic failure. Non-dialyzed severe renal failure. Pregnancy & lactation. Childn <15 yr.
Risk of GI ulceration, bleeding & perforation. Increased risk of serious CV events eg, MI; HTN; fluid retention or heart failure; history of serious GI events; smoking, alcoholism. Severe skin reactions eg, exfoliative dermatitis, toxic epidermal necrolysis or Stevens-Johnson syndrome. Concomitant use w/ corticosteroids. Avoid use during pregnancy. Not to be used during lactation. Not recommended in childn <15 yr. Elderly or debilitated patients.