Axcel Ciprofloxacin

Axcel Ciprofloxacin

ciprofloxacin

Manufacturer:

Kotra Pharma

Distributor:

Kotra Pharma
Concise Prescribing Info
Contents
Ciprofloxacin HCl
Indications/Uses
Uncomplicated & complicated resp tract infections; otitis media & sinusitis. Eyes, kidneys &/or efferent urinary tract, GIT, biliary tract, skin & soft tissue, bone & joint infections. Adnexitis, gonorrhoea & prostatitis; peritonitis; sepsis. Prophylaxis in immunocompromised patients. Selective intestinal decontamination in immunocompromised patients. Post-exposure anthrax inhalation in adults & childn.
Dosage/Direction for Use
Adult Resp tract infection 500-750 mg bd for 7-14 days. Acute, uncomplicated UTI 250-500 mg bd for 7 days. Cystitis in women & acute, uncomplicated gonorrhea 500 mg single dose. Complicated UTI & adnexitis, prostatitis, epididymo-orchitis 500-750 mg bd for 7 days. Extragenital gonorrhea 250 mg bd for 7-14 days. Diarrhea, other infections & post-exposure anthrax inhalation 500 mg bd for 7-14 days. Severe, life-threatening infections caused by Pseudomonas, Staph or Strep 750 mg bd for at least 10 days. Prophylaxis of invasive infections due to Neisseria meningitides 500 mg single dose. CrCl 30-60 mL/min/1.73 m2 Max daily dose: 1,000 mg. CrCl <30 mL/min/1.73 m2 Max daily dose: 500 mg. Childn & adolescents Bronchopulmonary infection associated w/ P aeruginosa 20 mg/kg bd for 10-14 days. Max: 750 mg/dose. Complicated UTI & pyelonephritis 10-20 mg/kg bd for 10-21 days. Max: 750 mg/dose. Post-exposure anthrax inhalation 15 mg/kg bd. Max: 500 mg/dose.
Administration
May be taken with or without food: May be taken w/ meals to minimize GI discomfort. Do not take w/ antacids, Fe or dairy products.
Contraindications
Hypersensitivity to ciprofloxacin or other quinolones. Concurrent administration w/ tizanidine.
Special Precautions
Discontinue use if severe anaphylactic/anaphylactoid reaction, severe & persistent diarrhoea, epilepsy, lowered convulsion threshold, previous history of convulsion, reduced cerebral blood flow, altered brain structure/stroke, tendon swelling/inflammation or tendon rupture & photosensitisation occur. Kidney, heart & lung transplant recipients. History of myasthenia gravis. Avoid direct exposure to excessive sunlight or UV light. Concomitant use w/ CYP450 1A2 inhibitors (eg, theophylline, methylxanthines, caffeine, duloxetine, clozapine) & corticosteroids. May affect ability to drive & use machines. Not to be used during pregnancy & lactation.
Adverse Reactions
Nausea, diarrhea.
Drug Interactions
Reduced absorption w/ multivalent cation-containing drugs & mineral supplements (eg, Ca, Mg, Al, Fe), polymeric phosphate binders (eg, sevelamer), sucralfate or Mg-, Al-, or Ca-containing antacids & highly buffered drugs (eg, didanosine tab) & dairy products or mineral fortified drinks (eg, milk, yoghurt, calcium fortified orange juice). Reduced Cmax & AUC w/ omeprazole. Increased serum theophylline conc. Provoked convulsions w/ certain NSAIDs (but not acetylsalicylic acid). Transient rise in serum creatinine conc w/ cyclosporine. Intensified action of warfarin & glibenclamide. Increased serum conc by probenecid. Increased plasma levels of methotrexate. Accelerated absorption by metoclopramide. Increased tizanidine serum conc. Increased Cmax & AUC of duloxetine & ropinirole. Reduced clearance of IV lidocaine. Increased serum conc of clozapine & N-desmethylclozapine.
MIMS Class
ATC Classification
J01MA02 - ciprofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Presentation/Packing
Form
Axcel Ciprofloxacin FC tab 250 mg
Packing/Price
10 × 10's
Form
Axcel Ciprofloxacin FC tab 500 mg
Packing/Price
10 × 10's
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