Reduced absorption w/ multivalent cation-containing drugs & mineral supplements (eg, Ca, Mg, Al, Fe), polymeric phosphate binders (eg, sevelamer), sucralfate or Mg-, Al-, or Ca-containing antacids & highly buffered drugs (eg, didanosine tab) & dairy products or mineral fortified drinks (eg, milk, yoghurt, calcium fortified orange juice). Reduced Cmax
& AUC w/ omeprazole. Increased serum theophylline conc. Provoked convulsions w/ certain NSAIDs (but not acetylsalicylic acid). Transient rise in serum creatinine conc w/ cyclosporine. Intensified action of warfarin & glibenclamide. Increased serum conc by probenecid. Increased plasma levels of methotrexate. Accelerated absorption by metoclopramide. Increased tizanidine serum conc. Increased Cmax
& AUC of duloxetine & ropinirole. Reduced clearance of IV lidocaine. Increased serum conc of clozapine & N-desmethylclozapine.