Axcel Glimepiride

Axcel Glimepiride

glimepiride

Manufacturer:

Kotra Pharma

Distributor:

Kotra Pharma
Concise Prescribing Info
Contents
Glimepiride
Indications/Uses
Adjunct to diet & exercise in NIDDM (type II) when blood sugar levels are inadequately controlled by diet, physical exercise & wt reduction alone, may be used in combination w/ metformin-containing oral antidiabetic or insulin.
Dosage/Direction for Use
Initially 1 mg daily, may be increased gradually at intervals of 1-2 wk in stepwise manner: 2, 3, or 4 mg daily. Max: 6 mg daily.
Administration
Should be taken with food: Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.
Contraindications
Hypersensitivity to glimepiride, other sulfonylureas or sulfonamides. Insulin-dependent diabetes, diabetic coma, ketoacidosis. Severe renal or hepatic disorders.
Special Precautions
Hypoglycaemia; signs of adrenergic counter-regulation; thyroid function disorders, arterior pituitary or adrenocortical insufficiency. Increased risk of CV mortality. Malnutrition, irregular mealtimes or missed meals or periods of fasting; diet alterations; physical exertion & carbohydrate intake imbalance. Regularly monitor blood glucose levels, determine HbA1c, hepatic function & haematological levels. G6PD deficiency. Alcohol consumption. May affect ability to drive & use machines. Serious hepatic dysfunction; renal impairment. Not to be used during pregnancy & lactation. Not recommended in childn <17 yr. Elderly.
Adverse Reactions
Transient visual impairment; increased hepatic enzymes; hypersensitivity eg, pruritus, rash, urticaria, photosensitivity.
Drug Interactions
Increased AUC w/ fluconazole. Potentiated blood glucose-lowering effect w/ phenylbutazone, azapropazone, oxyfenbutazone; insulin, oral antidiabetics eg, metformin; salicylates, p-amino-salicylic acid; anabolic steroids, male sex hormones; chloramphenicol, long-acting sulfonamides, tetracyclines, quinolones, clarithromycin; coumarin anticoagulants; fenfluramine; fibrates; ACE inhibitors; fluoxetine, MAOIs; allopurinol, probenecid, sulfinpyrazone; sympatholytics; cyclophosphamide, trophosphamide, iphosphamides; miconazole; pentoxifylline (high dose IV); tritoqualine. Weakened blood glucose-lowering effect w/ oestrogens, progestogens; saluretics, thiazide diuretics; thyroid-stimulating agents, glucocorticoids; phenothiazine derivatives, chlorpromazine; adrenaline, sympathicomimetics; nicotinic acid (high dose) & derivatives; laxatives (long-term use); phenytoin, diaxozide; glucagon, barbiturates, rifampicin; acetazolamide. Potentiated or weakened blood glucose-lowering effect w/ H2-antagonists, β-blockers, clonidine, reserpine. Potentiated or weakened hypoglycaemic action w/ alcohol. Potentiated or weakened effects of coumarin derivatives.
MIMS Class
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
Presentation/Packing
Form
Axcel Glimepiride tab 2 mg
Packing/Price
4 × 7's
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