Azarga

Azarga

brinzolamide + timolol

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Per mL Brinzolamide 10 mg, timolol 5 mg
Indications/Uses
Decreased IOP in adult patients w/ open-angle glaucoma or ocular HTN for whom monotherapy provides insufficient IOP reduction.
Dosage/Direction for Use
1 drop into conjunctival sac of affected eye(s) bd.
Contraindications
Hypersensitivity to brinzolamide, timolol, other β-blockers, sulphonamides. Reactive airway disease including bronchial asthma or history of bronchial asthma, severe COPD. Sinus bradycardia, sick sinus syndrome, SA block, 2nd- or 3rd-degree AV block, overt cardiac failure or cardiogenic shock. Severe allergic rhinitis. Hyperchloraemic acidosis. Severe renal impairment.
Special Precautions
Discontinue use if signs of serious reactions or hypersensitivity occur. History of atopy or severe anaphylactic reaction to variety of allergens. Patients w/ compromised corneas eg, patients w/ DM or corneal dystrophies; CV diseases (eg, CHD, Prinzmetal's angina, cardiac failure), hypotension; severe peripheral circulatory disturbance/disorders; resp reactions including death due to bronchospasm in patients w/ asthma. Hyperchloraemic acidosis; spontaneous hypoglycaemia or labile diabetes; hyperthyroidism; muscle weakness consistent w/ certain myasthenic symptoms eg, diplopia, ptosis, generalized weakness; choriodal detachment. Remove contact lens prior to application & wait 15 min before reinsertion. Concomitant use w/ surgical anaesth. Not recommended to use 2 local β-blockers or carbonic anhydrase inhibitors. May affect ability to drive & use machines. Renal impairment. Not to be used during pregnancy. Lactation. Not recommended in childn <18 yr.
Adverse Reactions
Dysgeusia, punctate keratitis, blurred vision, eye pain & irritation, decreased heart rate.
Drug Interactions
Acid-base disturbances & additive effect w/ oral carbonic anhydrase inhibitors. Inhibited metabolism by CYP3A4 inhibitors eg, ketoconazole, itraconazole, clotrimazole, ritonavir, troleandomycin. Potentiated systemic β-blockade w/ CYP2D6 inhibitors eg, quinidine, fluoxetine, paroxetine. Hypotension &/or marked bradycardia w/ oral Ca-channel blockers, β-blockers, antiarrythmics (eg, amiodarone), digitalis glycosides, parasympathomimetics or guanethidine. Potentiated effect on IOP w/ systemic β-blockers. Potentiated hypertensive reaction to sudden w/drawal of clonidine. Increased hypoglycaemic effect of antidiabetic agents. Mydriasis w/ adrenaline.
MIMS Class
Antiglaucoma Preparations
ATC Classification
S01ED51 - timolol, combinations ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Presentation/Packing
Form
Azarga eye susp
Packing/Price
5 mL x 1's
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