Acid-base disturbances & additive effect w/ oral carbonic anhydrase inhibitors. Inhibited metabolism by CYP3A4 inhibitors eg, ketoconazole, itraconazole, clotrimazole, ritonavir, troleandomycin. Potentiated systemic β-blockade w/ CYP2D6 inhibitors eg, quinidine, fluoxetine, paroxetine. Hypotension &/or marked bradycardia w/ oral Ca-channel blockers, β-blockers, antiarrythmics (eg, amiodarone), digitalis glycosides, parasympathomimetics or guanethidine. Potentiated effect on IOP w/ systemic β-blockers. Potentiated hypertensive reaction to sudden w/drawal of clonidine. Increased hypoglycaemic effect of antidiabetic agents. Mydriasis w/ adrenaline.