Azelaic acid


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical Acne vulgaris As 20% cream or 15% gel: Apply onto the affected areas bid. Rosacea As 15% gel: Apply onto the affected areas bid.
Dosage Details
Topical/Cutaneous
Acne vulgaris
Adult: As 20% cream or 15% gel: Apply thinly into the affected areas bid (morning and evening) after cleansing. Improvement may be detectable w/n 4 wk. Duration of treatment: Up to 6 mth.
Child: ≥12 yr Same as adult dose.

Topical/Cutaneous
Rosacea
Adult: As 15% gel: Apply thinly into the affected areas bid (morning and evening). Improvement occurs in 4-8 wk.
Child: ≥12 yr Same as adult dose.
Special Patient Group
Acne vulgaris:
Patients w/ sensitive skin: As 20% cream: Apply once daily (in the evening) for 1 wk then apply bid thereafter.
Special Precautions
Patient w/ sensitive skin. Not intended for application to broken, sunburnt or eczematous skin. Avoid use of occlusive dressing or wrappings. Pregnancy and lactation.
Adverse Reactions
Burning, erythema, stinging, pruritus, dryness and scaling, peeling, irritation, dermatitis, hypopigmentation, rash, and photosensitivity. Rarely, exacerbation of asthma.
MonitoringParameters
Monitor for hypopigmentation in patients w/ dark complexion.
Food Interaction
Avoid spicy foods, alcoholic beverages and hot drinks that might provoke erythema, flushing and blushing during treatment of rosacea.
Action
Description: Azelaic acid is a naturally-occurring aliphatic dicarboxylic acid that inhibits the growth of Propionibacterium acnes and reduces keratinisation, thus restricts the development of comedones.
Onset: W/n 4 wk.
Pharmacokinetics:
Absorption: Approx 4% absorbed systemically.
Distribution: Penetrates all layers of the skin.
Metabolism: Metabolised via β-oxidation into short-chained dicarboxylic acids (C7, C5).
Excretion: Via urine (mainly as unchanged drug and some as dicarboxylic acids). Half-life: 12 hr.
Chemical Structure

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Storage
Store between 15-30°C.
ATC Classification
D10AX03 - azelaic acid ; Belongs to the class of other topical preparations used in the treatment of acne.
Disclaimer: This information is independently developed by MIMS based on Azelaic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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