Bacitracin + Polymyxin B


Generic Medicine Info
Indications and Dosage
Ophthalmic
Superficial ocular infections
Adult: As oint containing bacitracin 500 U and polymyxin B 10,000 U/g: Apply to affected eye(s) 3-4 hrly for 7-10 days, depending on severity of infection.

Topical/Cutaneous
Superficial infections
Adult: As oint containing bacitracin 500 U and polymyxin B 10,000 U/g: Apply thinly to affected area 1-3 times daily, may be covered w/ a sterile bandage.
Child: Same as adult dose.
Contraindications
Hypersensitivity to bacitracin or polymyxin B.
Special Precautions
Prolonged use may cause overgrowth of nonsusceptible organisms, including fungi. Pregnancy and lactation.
Adverse Reactions
Burning sensation, local irritation, swelling, conjunctival erythema, pruritus (ophth). Rarely, anaphylaxis.
Action
Description: Bacitracin interferes w/ bacterial cell wall synthesis by inhibition of the regeneration of phospholipid receptors involved in peptidoglycan synthesis. It is bactericidal to a number of gram +ve and –ve organisms. Polymyxin B increases the permeability of the bacterial cytoplasmic membrane by interacting w/ the phospholipid components. It is bactericidal to a number of gram –ve organisms.
Pharmacokinetics:
Absorption: Poorly absorbed from intact or denuded skin, wounds, or mucous membranes.
Chemical Structure

Chemical Structure Image
Bacitracin

Source: National Center for Biotechnology Information. PubChem Database. CID=11980094, https://pubchem.ncbi.nlm.nih.gov/compound/Bacitracin-methylene-disalicylate (accessed on Jan. 21, 2020)


Chemical Structure Image
Polymyxin B

Source: National Center for Biotechnology Information. PubChem Database. Polymyxin b, CID=49800004, https://pubchem.ncbi.nlm.nih.gov/compound/Polymyxin-b (accessed on Jan. 21, 2020)

Storage
Store between 15-25°C.
MIMS Class
Eye Anti-Infectives & Antiseptics / Topical Antibiotics
References
Anon. Bacitracin (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 24/01/2017.

Anon. Bacitracin and Polymyxin B (Ophthalmic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/09/2016.

Anon. Bacitracin and Polymyxin B (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/09/2016.

Bacitracin Zinc and Polymyxin B Sulfate (E. Fougera & Co., A division of Nycomed US Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2016.

Bacitracin Zinc and Polymyxin B Sulfate Ointment (Bausch & Lomb Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2016.

Buckingham R (ed). Bacitracin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/09/2016.

Buckingham R (ed). Polymyxin B Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/09/2016.

Joint Formulary Committee. Bacitracin w/ Polymyxin B. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/09/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Bacitracin, Bacitracin Zinc (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/09/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Bacitracin, Bacitracin Zinc (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/09/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Polymyxin B Sulfate (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/09/2016.

Polysporin First Aid Antibiotic (Johnson & Johnson Consumer Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2016.

Disclaimer: This information is independently developed by MIMS based on Bacitracin + Polymyxin B from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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