Bacitracin + Polymyxin B


Concise Prescribing Info
Indications/Uses
Superficial infections.
Dosage/Direction for Use
Adult : Topical Each g oint contains bacitracin 500 U and polymyxin B 10,000 U: Apply thinly to affected area 1-3 times/day. Ophth Each g oint contains bacitracin 500 U and polymyxin B 10,000 U: Apply to affected eye(s) 3-4 hrly for 7-10 days.
Dosage Details
Ophthalmic
Superficial ocular infections
Adult: As oint containing bacitracin 500 U and polymyxin B 10,000 U/g: Apply to affected eye(s) 3-4 hrly for 7-10 days, depending on severity of infection.

Topical/Cutaneous
Superficial infections
Adult: As oint containing bacitracin 500 U and polymyxin B 10,000 U/g: Apply thinly to affected area 1-3 times daily, may be covered w/ a sterile bandage.
Child: Same as adult dose.
Contraindications
Hypersensitivity to bacitracin or polymyxin B.
Special Precautions
Prolonged use may cause overgrowth of nonsusceptible organisms, including fungi. Pregnancy and lactation.
Adverse Reactions
Burning sensation, local irritation, swelling, conjunctival erythema, pruritus (ophth). Rarely, anaphylaxis.
Action
Description: Bacitracin interferes w/ bacterial cell wall synthesis by inhibition of the regeneration of phospholipid receptors involved in peptidoglycan synthesis. It is bactericidal to a number of gram +ve and –ve organisms. Polymyxin B increases the permeability of the bacterial cytoplasmic membrane by interacting w/ the phospholipid components. It is bactericidal to a number of gram –ve organisms.
Pharmacokinetics:
Absorption: Poorly absorbed from intact or denuded skin, wounds, or mucous membranes.
Chemical Structure

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Storage
Store between 15-25°C.
Disclaimer: This information is independently developed by MIMS based on Bacitracin + Polymyxin B from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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