Adult: Acute attack: 2.25 g tid, until remission occurs or up to 12 wk. Maintenance: 1.5 g bid, adjusted according to response. Max: 6 g daily. Child: 5-17 yr 750 mg tid or 2.25 g tid, treatment may continue for up to 8 wk.
Moderate to severe: Contraindicated.
cap: May be taken with or without food. May be swallowed whole or sprinkle entire contents on applesauce. Take mixt immediately; the contents may be chewed. Do not store for future use.
Severe hepatic and moderate to severe renal impairment.
Patient w/ pyloric stenosis, asthma, bleeding disorders, active peptic ulcer disease. Mild to moderate hepatic and mild renal impairment or history of renal disease. Pregnancy and lactation.
Symptoms: Nausea, vomiting, diarrhoea. Management: Supportive and symptomatic treatment.
Increased risk of blood dyscrasias w/ azathioprine and 6-mercaptopurine. Increased nephrotoxicity when used w/ NSAIDs. May decreased serum concentration of cardiac glycosides.
Description: Balsalazide is a prodrug of mesalazine which is linked to 4-aminobenzoyl-β-alanine via an azo bond. W/ the release of mesalazine, it reduces inflammation by inhibiting cyclooxygenase and leukotriene synthesis, thus blocking the formation of arachidonic acid in the colonic mucosa. Pharmacokinetics: Absorption: Time to peak plasma concentration: 1-2 hr (balsalazide); 9-10hr (mesalazine). Distribution: Plasma protein binding: Approx 99%. Metabolism: Undergoes bacterial azoreduction in the colon to 5-aminosalicylic acid (mesalazine, active), 4-aminobenzoyl-β-alanine (inert), and N-acetylated metabolites; 4-aminobenzoylalanine undergoes hepatic first-pass metabolism. Excretion: Mainly via faeces (approx 65%, as mesalazine, 4-aminobenzoyl-β-alanine or N-acetylated metabolites); urine (approx 25%, as N-acetylated metabolites); <1% via urine or faeces (as unchanged drug). Elimination half-life: 6-9 hr (as N-acetylated metabolites); approx. 1 hr (mesalazine).
A07EC04 - balsalazide ; Belongs to the class of aminosalicylic acid and similar antiinflammatory. Used in the treatment of intestinal inflammation.
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