Betacarotene


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Prevention of vit A deficiency 6-15 mg/day. Reduce severity of photosensitivity reactions in patients w/ erythropoietic protoporphyria 30-300 mg/day.
Dosage Details
Oral
Prophylaxis of vitamin A deficiency
Adult: 6-15 mg daily.
Child: 3-6 mg daily.

Oral
Reduction of severity of photosensitivity reactions in patients with erythropoietic protoporphyria
Adult: 30-300 mg daily. Generally, 2-6 wk of treatment is needed before patients should attempt to increase their exposure to sunlight.
Child: 30-150 mg daily. Generally, 2-6 wk of treatment is needed before patients should attempt to increase their exposure to sunlight.
Administration
Should be taken with food.
Special Precautions
Excess intake may cause yellow discoloration of the skin.
Adverse Reactions
Loose stools, bruising, dizziness and arthralgia.
Action
Description: Betacarotene is a carotenoid precursor of vitamin A. Vitamin A is needed for healthy skin function and repair, night vision, maintenance of healthy mucous membranes including stomach and lungs. It is also an antioxidant that reduces risk of cellular damage caused by free radicals.
Pharmacokinetics:
Absorption: GI absorption depends on the presence of bile and is increased by dietary fat.
Distribution: Unchanged betacarotene: Distributed to various tissues e.g. fat, adrenal glands and ovaries.
Metabolism: 20-60% is metabolised to retinol in the intestinal wall, and a small amount is converted to vitamin A hepatically.
Disclaimer: This information is independently developed by MIMS based on Betacarotene from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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