Zuellig Pharma
Concise Prescribing Info
Metoprolol tartrate
HTN; angina pectoris; MI. Cardiac rhythm disturbances including supraventricular tachycardia. Functional heart disorders w/ palpitations. Migraine prophylaxis. Hyperthyroidism.
Dosage/Direction for Use
HTN 100-200 mg as single or divided dose. Angina pectoris, cardiac arrhythmias, migraine prophylaxis 100-200 mg daily in 2 divided doses. Prophylactic therapy after MI 100 mg in morning & evening. Functional heart disorders w/ palpitations 100 mg once daily as single dose in the morning, may be increased to 200 mg. Hyperthyroidism 150-200 mg daily in 3-4 divided doses.
Should be taken on an empty stomach.
Hypersensitivity to metoprolol or other β-blockers. Cardiogenic shock. Sick-sinus syndrome. 2nd & 3rd degree AV block. Unstable, decompensated heart failure; inotropic therapy acting through β-receptor agonism. Symptomatic bradycardia or hypotension. Suspected acute MI (heart rate <45 beats/min, PQ interval >0.24 sec or systolic BP <100 mmHg). Serious peripheral vascular disease w/ gangrene threat.
Special Precautions
Not to be given in latent or manifested heart insufficiency w/o concomitant treatment. Prinzmetal's angina; bronchial asthma or other COPD; phaeochromocytoma; known ischemic heart disease; peripheral artery circulatory disorders eg, intermittent claudication; serious acute conditions w/ metabolic acidosis. Risk for interfering w/ carbohydrate metabolism or masking hypoglycaemia. Surgery. Avoid abrupt w/drawal. Not to be given w/ IV verapamil. Combination w/ digitalis. Galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Hepatic impairment eg, shunt-operated patients. Severe renal impairment. Not to be given during pregnancy & lactation. Childn.
Adverse Reactions
Fatigue. Bradycardia, palpitations; dizziness, headache; shortness of breath; abdominal pain, nausea, vomiting, diarrhea, constipation; peripheral coldness in extremities.
Drug Interactions
Induced metabolism w/ barbituric acid derivatives. Increased plasma conc w/ propafenone, cimetidine, hydralazine. Additive inhibitory effects w/ verapamil, diltiazem. Pronounced sinus bradycardia w/ amiodarone. Additive -ve inotropic effects w/ class I antiarrhythmics. Counteracted antihypertensive effects w/ NSAIDs. Decreased clearance w/ diphenhydramine. Increased AV conduction time & induced bradycardia w/ digitalis glycosides. Pronounced HTN & sinus bradycardia w/ epinephrine. Increased diastolic BP w/ phenylypropanolamine. Inhibited metabolism w/ quinidine. Potentiated hypertensive reaction w/ clonidine. Decreased plasma levels w/ rifampicin. Enhanced cardio-depressant effect w/ inhalation anaesth.
MIMS Class
ATC Classification
C07AB02 - metoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Betaloc tab 100 mg
Betaloc tab 50 mg
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