Sick-sinus syndrome (provided there is no permanent pacemaker).
AV-block of second and third degree.
Patients with unstable, decompensated heart failure (pulmonary oedema, hypoperfusion or hypotension), and patients with continuous or intermittent inotropic therapy acting through beta-receptor agonism.
Symptomatic bradycardia or hypotension. Metoprolol should not be given to patients with suspected acute myocardial infarction as long as the heart rate is <45 beats/min, the P-Q interval is >0.24 sec or the systolic blood pressure is <100 mm Hg.
Serious peripheral vascular disease with gangrene threat.
Hypersensitivity to the active substance, to other beta-blockers or to any of the excipients specified in Description.