Betamethasone + Gentamicin


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses with secondary infection
Adult: Available preparation:
Betamethasone 0.5 mg (0.05%) and gentamicin 1 mg (0.1%) cream or ointment

Apply a thin film onto affected area bid. Duration of treatment varies according to patient response and extent and location of disease. Reassess diagnosis, if no clinical improvement after 3-4 weeks.
Contraindications
Hypersensitivity. Viral diseases (e.g. varicella, herpes simplex, vaccinia), TB of the skin.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Significant: Adrenal suppression (particularly when used in younger children or patients receiving high doses for prolonged periods), allergic contact dermatitis, hypersensitivity reactions, local sensitisation (redness, irritation), secondary bacterial or fungal superinfection (prolonged use), visual disturbances (e.g. blurred vision), posterior subcapsular cataracts, glaucoma, hyperglycaemia, glycosuria; delayed weight gain, intracranial hypertension, growth retardation in children. Rarely, Cushing syndrome, central serous chorioretinopathy.
Skin and subcutaneous tissue disorders: Rash, dryness, burning, itching, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, skin atrophy, striae, miliaria, maceration of the skin.
Monitoring Parameters
Monitor HPA axis suppression and adrenal insufficiency (particularly in children), ocular symptoms.
Lab Interference
Betamethasone: May suppress the flare and wheal reactions to skin test antigens.
Action
Description: Betamethasone is a corticosteroid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces the phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thus leading to reduction of the formation, release, and activity of endogenous chemical mediators of inflammation (e.g. kinins, histamine, prostaglandins, liposomal enzymes).
Gentamicin is a broad-spectrum aminoglycoside antibiotic which interferes with the bacterial protein synthesis by binding to the 30S and 50S ribosomal subunit of susceptible bacteria, thus rendering the bacterial cell membrane defective.
Pharmacokinetics:
Absorption: Betamethasone: Absorbed percutaneously (variable).
Gentamicin: Absorbed (systemic) following topical administration on denuded skin and burns.
Metabolism: Betamethasone: Metabolised in the liver.
Excretion: Betamethasone: Via urine and bile.
Chemical Structure

Chemical Structure Image
Betamethasone

Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)


Chemical Structure Image
Gentamicin

Source: National Center for Biotechnology Information. PubChem Database. Gentamicin, CID=3467, https://pubchem.ncbi.nlm.nih.gov/compound/Gentamicin (accessed on Jan. 22, 2020)

Storage
Store below 30°C. Protect from strong light.
ATC Classification
D07CC01 - betamethasone and antibiotics ; Belongs to the class of potent (group III) corticosteroids, in combination with antibiotics. Used in the treatment of dermatological diseases.
References
Anon. Betamethasone (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2021.

Anon. Betamethasone and Gentamicin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2021.

Anon. Gentamicin (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2021.

Beprogent Ointment/Cream (HOE Pharmaceuticals Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 07/04/2021.

Buckingham R (ed). Betamethasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/04/2021.

Buckingham R (ed). Gentamicin Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/04/2021.

Diprogenta Cream and Ointment (Merck Sharp & Dohme [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 07/04/2021.

Disclaimer: This information is independently developed by MIMS based on Betamethasone + Gentamicin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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