Betamox

Betamox

amoxicillin

Manufacturer:

Duopharma (M)

Distributor:

Duopharma Marketing
Concise Prescribing Info
Contents
Amoxicillin trihydrate
Indications/Uses
Cap/granules: Skin & skin structure, acute & chronic resp infections, complicated & uncomplicated, acute & chronic GUT infections; gonorrhoea. Prophylaxis of endocarditis. Tab: Lyme disease; typhoid fever. Prophylaxis of spleen disorders & bacterial endocarditis. Adjunct for H pylori-associated peptic ulcer. Alternative to erythromycin for chlamydial infections in pregnant women.
Dosage/Direction for Use
Cap/granules Upper resp tract, GUT, skin & soft tissue infections Adult 250 mg 8 hrly. Childn 20 mg/kg daily 8 hrly. Severe infections Adult 500 mg 8 hrly. Childn 40 mg/kg daily 8 hrly. Lower resp tract infections Adult 500 mg 8 hrly. Childn <20 kg 40 mg/kg daily 8 hrly. Gonococcal urethritis Adult 3 g as single dose. Acute, uncomplicated lower UTI in female 3 g as single dose. Peritoneal dialysis Max: 500 mg daily. Tab Adult Severe or recurrent resp tract infections 3 g bd. Uncomplicated endocervical & urethral gonorrhoea 3 g as single dose w/ probenecid 1 g. Dental abscesses/uncomplicated UTI 3 g repeated once after 8 or 10-12 hr. Chlamydia in pregnant women 500 mg every 8 hr for 7-10 days. Prophylaxis of endocarditis 3 g 1 hr before dental procedures under local or no anaesth then 1.5 g 6 hr after initial dose. H pylori-associated gastritis or peptic ulcer 500 mg qds or 750 mg tds. Lyme disease 250-500 mg tds-qds for 3-4 wk. Childn up to 10 yr 125-250 mg every 8 hr, <20 kg 20-40 mg/kg daily. Otitis media in childn 3-10 yr 750 mg bd for 2 days. Uncomplicated endocervical & urethral gonorrhoea 50 mg/kg w/ probenecid 25 mg/kg as single dose in prepubertal childn. Lyme disease 6.7-13.3 mg/kg every 8 hr for 10-30 days.
Administration
May be taken with or without food: May be taken w/ meals for better absorption.
Contraindications
Hypersensitivity to β-lactams eg, penicillins, cephalosporins. Presence of bleeding disorders, GI disease, infectious mononucleosis. Renal impairment.
Special Precautions
Hypersensitivity to penicillins, cephalosporins, carbapenems, other β-lactams & allergens. Discontinue use if superinfections occur. Antibiotic-associated pseudomembranous colitis, lymphatic leukaemia. Periodic assessment of renal, hepatic & haematopoietic functions in prolonged treatment. Increased ALT, AST & serum lactate dehydrogenase. False positive urine glucose reaction. Maintain adequate fluid intake & urinary output in high doses. May affect ability to drive & use machines. Renal impairment. Pregnancy & lactation.
Adverse Reactions
Anaphylaxis; anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leucopenia, neutropenia, agranulocytosis. Tab: GI reactions eg, mild diarrhoea, nausea, vomiting; headache; oral & vag candidiasis; pseudomembranous colitis.
Drug Interactions
Reduced OCs effectiveness. Increased frequency of skin rashes w/ allopurinol. Decreased renal tubular secretion w/ probenecid. Decreased methotrexate clearance. ACE inhibitors, K-sparing diuretics, K supplements.
MIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Presentation/Packing
Form
Betamox cap 250 mg
Packing/Price
100 × 10's
Form
Betamox cap 500 mg
Packing/Price
50 × 10's
Form
Betamox granules for oral soln 125 mg/5 mL
Packing/Price
60 mL x 1's
Form
Betamox granules for oral soln 250 mg/5 mL
Packing/Price
60 mL x 1's
Form
Betamox tab 500 mg
Packing/Price
50 × 10's
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