Generic Medicine Info
Indications and Dosage
Skin fungal infections
Adult: Skin mycoses caused by dermatophytes, yeasts, moulds, and other fungi (e.g. tinea pedis, tinea manuum, tinea corporis, tinea cruris): As 1% cream: Apply thinly onto the affected area(s) once daily, preferably at night. Treatment duration: 2-4 weeks.
Hypersensitivity. Treatment of nail, scalp and vaginal infections, and infants with diaper rash.
Special Precautions
Patient with history of hypersensitivity reactions to other imidazole antifungal agents (e.g. clotrimazole, econazole, miconazole). Pregnancy and lactation.
Adverse Reactions
Significant: Hypersensitivity reactions.
General disorders and administration site conditions: Application site pain and peripheral oedema.
Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, urticaria, dry skin, skin irritation and maceration, skin burning sensation, eczema, blister, skin exfoliation, contact and allergic dermatitis.
Patient Counseling Information
Avoid contact with eyes and mucous membranes.
Drug Interactions
May possibly lead to an increase in INR of warfarin.
Mechanism of Action: Bifonazole is an imidazole derivative broad spectrum antifungal agent. It inhibits the biosynthesis of ergosterol, thereby resulting in structural and functional impairment of the cytoplasmic membrane.
Absorption: Well absorbed into infected skin layers; increased in inflamed skin.
Excretion: Via urine (45%); faeces (40%). Elimination half-life: Biphasic: 8 hours and 50 hours.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2378, Bifonazole. Accessed July 27, 2022.

Store below 30°C.
MIMS Class
Topical Antifungals & Antiparasites
ATC Classification
D01AC10 - bifonazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
Anon. Bifonazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 04/07/2022.

Buckingham R (ed). Bifonazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 04/07/2022.

Canesten Bifonazole Once Daily 1% w/w Cream (Bayer plc). MHRA. Accessed 04/07/2022.

Canesten Extra (Bayer HealthCare Limited). MIMS Hong Kong. Accessed 04/07/2022.

Disclaimer: This information is independently developed by MIMS based on Bifonazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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