Bifonazole


Concise Prescribing Info
Indications/Uses
Fungal skin and nail infections.
Dosage/Direction for Use
Adult : Topical As 1% cream/powd/soln/gel: Apply once daily at night for 2-4 wk, or longer for nail infection.
Dosage Details
Topical/Cutaneous
Nail fungal infections, Skin fungal infections
Adult: As 1% cream, powder, soln or gel: Apply thinly onto affected areas once daily, preferably at night for 2-4 wk. For nail infections, longer treatment may be necessary; 40% urea paste may be applied initially to soften the nails.
Contraindications
Hypersensitivity to bifonazole.
Special Precautions
Patient w/ history of hypersensitivity reactions to other imidazole antifungals (e.g. econazole, miconazole, clotrimazole). Pregnancy and lactation.
Adverse Reactions
Burning sensation, contact dermatitis, erythema, pruritus, rash, urticaria, blister, skin exfoliation, eczema, dry skin, skin irritation or maceration, peripheral oedema at admin site. Very rarely, systemic hypersensitivity reactions.
Patient Counseling Information
Avoid contact w/ eyes, nose, mouth or other mucous membranes.
Drug Interactions
Possible increase in INR when used w/ warfarin.
Action
Description: Bifonazole is an imidazole derivative w/ broad antifungal spectrum. It inhibits ergosterol synthesis resulting in structural and functional impairment of the fungal cytoplasmic membrane. It also exhibits some antibacterial activity.
Pharmacokinetics:
Absorption: Absorbed well into infected skin.
Distribution: Penetrates various skin layers including the stratum corneum and stratum papillare.
Excretion: Via urine (45%) and faeces (40%). Elimination half-life: Biphasic: 8 hr and 50 hr.
Chemical Structure

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Storage
Store below 30°C.
ATC Classification
D01AC10 - bifonazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
Disclaimer: This information is independently developed by MIMS based on Bifonazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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