The adverse effects described as follows are sorted according to system organ classes. Frequencies are classified as follows: Very common (affects more than 1person in 10), Common (affects less than 1person in 10), Uncommon (affects less than 1person in 100), Rare (affects less than 1 person in 1,000), Very rare (affects less than 1 person in 10,000).
Cardiac disorders: Very common: bradycardia (in patients with chronic heart failure). Common: worsening of pre-existing heart failure (in patients with chronic heart failure). Uncommon: AV-conduction disturbances; bradycardia (in patients with hypertension or angina pectoris): worsening of pre-existing heart failure (in patients with hypertension or angina pectoris).
Investigations: Rare: increased triglycerides, increased liver enzymes (ALAT, ASAT).
Nervous system disorders: Common: dizziness*, headache*.
Eye disorders: Rare: reduced tear flow (to be considered if the patient uses contact lenses). Very rare: conjunctivitis.
Ear and labyrinth disorders: Rare: hearing disorders.
Respiratory, thoracic and mediastinal disorders: Uncommon: bronchospasm in patients with bronchial asthma or a history of Obstructive airways disease. Rare: allergic rhinitis.
Gastrointestinal disorders: Common: gastrointestinal complaints such as nausea, vomiting, diarrhoea, constipation.
Skin and subcutaneous tissue disorders: Rare: hypersensitivity reactions such as itching, flush, rash. Very rare: alopecia. Beta-blockers may provoke or worsen psoriasis or induce psoriasis like rash.
Musculoskeletal and connective tissue disorders: Uncommon: muscle weakness, muscle cramps.
Vascular disorders: Common: feeling of coldness or numbness in the extremities, hypotension especially in patients with heart failure.
General disorders: Common: asthenia (in patients with chronic heart failure), fatigue*. Uncommon: asthenia (in patients with hypertension or angina pectoris).
Hepatobilary disorders: Rare: hepatitis.
Reproductive system and breast disorders: Rare: potency disorders.
Psychiatric disorders: Uncommon: depression, sleep disorders. Rare: nightmares, hallucinations.
Applies only to patients with hypertension or angina pectoris.
*These symptoms especially occur at the beginning of the therapy. They are generally mild and usually disappear within 1-2 weeks.
Tell the doctor if the patient notice any of the side effects listed as previously mentioned or any other unwanted or unexpected effects. To prevent serious reactions, speak to a doctor immediately if a side effect is severe, occurred suddenly, or gets worse rapidly.