Incompatibilities: BONSPRI must not be mixed with other medicinal products.
Instructions for Use and Handling: Instructions for Use of BONSPRI pre-filled syringe: Be sure that the patient reads, understands, and follow these "Instructions for Use" before injecting BONSPRI. Talk to a healthcare provider if the patient has any questions before using BONSPRI for the first time.
Remember: Do not use the BONSPRI pre-filled syringe if either the seal on the outer carton or the seal of the blister is broken. Keep the BONSPRI pre-filled syringe in the sealed carton until the patient is ready to use it.
Do not shake the BONSPRI pre-filled syringe.
The pre-filled syringe has a needle guard that will be activated to cover the needle after the injection is finished. The needle guard will help to prevent needle stick injuries to anyone who handles the pre-filled syringe after injection.
Do not remove the needle cap until just before the patient gives the injection.
Avoid touching the syringe guard wings before use. Touching them may cause the needle guard to be activated too early.
Throw away (dispose of) the used BONSPRI pre-filled syringe right away after use. Do not re-use a BONSPRI pre-filled syringe. See "How should the patient dispose of used BONSPRI pre-filled syringe?" at the end of these "Instructions for Use".
How should the patient store BONSPRI? Store the carton of the BONSPRI pre-filled syringe in a refrigerator, 2°C to 8°C (between 36°F to 46°F).
Keep the BONSPRI pre-filled syringe in the original carton until ready to use to protect from light.
Do not freeze the BONSPRI pre-filled syringe.
What the patient needs for injection: Included in the carton: A new BONSPRI pre-filled syringe.
Not included in the carton: 1 alcohol wipe, 1 cotton ball or gauze, Sharps disposal container.
See "How should the patient dispose of used BONSPRI pre-filled syringes?" at the end of these "Instructions for Use".
Prepare the BONSPRI pre-filled syringe: Step 1. Find a clean, well-lit, flat work surface.
Step 2. Take the carton containing the BONSPRI pre-filled syringe out of the refrigerator and leave it unopened on the work surface for about 15 to 30 minutes so that it reaches room temperature.
Step 3. Wash the hands well with soap and water.
Step 4. Remove the pre-filled syringe from the outer carton and take it out of the blister by holding the syringe guard body.
Step 5. Look through the viewing window on the pre-filled syringe. The liquid inside should be clear to slightly cloudy. The patient may see a small air bubble in the liquid, which is normal. Do not use the pre-filled syringe if the liquid contains visible particles or is cloudy.
Step 6. Do not use the pre-filled syringe if it is broken. Return the pre-filled syringe and the package it came in to the pharmacy.
Step 7. Do not use the pre-filled syringe if the expiration date has passed. Return the expired pre-filled syringe and the package it came in to the pharmacy.
Choose and clean the injection site: Areas of the body that the patient may use as injection sites include: the front of thighs; the lower stomach-area (abdomen), but not the area five cm (2 inches) around the navel (belly button); the upper outer arms, if a healthcare provider or caregiver is giving the injection.
Choose a different site each time the patient injects BONSPRI.
Do not inject into areas where the skin is tender, bruised, red, scaly, or hard. Avoid areas with scars or stretch marks.
Step 8. Using a circular motion, clean the injection site with the alcohol wipe. Leave it to dry before injecting. Do not touch the cleaned area again before injecting.
Giving the injection: Step 9. Carefully remove the needle cap from the pre-filled syringe. Throw away the needle cap. The patient may see a drop of liquid at the end of the needle. This is normal.
Step 10. With one hand, gently pinch the skin at the injection site. With the other hand insert the needle into the skin. Push the needle all the way in to make sure that the patient injects full dose.
Step 11. Hold the pre-filled syringe finger grips. Slowly press down on the plunger as far as it will go, so that the plunger head is completely between the syringe guard wings.
Step 12. Continue to press fully on the plunger for an additional 5 seconds. Hold the syringe in place for the full 5 seconds.
Step 13. Slowly release the plunger until the needle is covered, and then remove the syringe from the injection site.
Step 14. There may be a small amount of blood at the injection site. The patient can press a cotton ball or gauze over the injection site and hold it for 10 seconds. Do not rub the injection site. The patient may cover the injection site with a small adhesive bandage, if needed.
How should the patient dispose of used BONSPRI pre-filled syringe? Step 15. Dispose of used pre-filled syringe: Dispose of the used pre-filled syringe in a sharps disposal container (i.e. a puncture-resistant closable container, or similar).
Do not throw away (dispose of) the used pre-filled syringe in household trash.
Never try to reuse the pre-filled syringe.
Keep the sharps container out of the reach of children.