Hypersensitivity to any of the tetracyclines.
In complete renal failure, minocycline, like other tetracycline class, should be discontinued as systemic accumulation of the drug may lead to liver toxicity.
Use in pregnancy: Minocycline, like other tetracycline-class antibiotics, can cause fetal harm when administered to a pregnant woman. If any tetracycline is used during pregnancy, or if the patient becomes pregnant while taking these drugs, potential hazard to the fetus should be considered.
Use in lactation: Tetracyclines are excreted in human milk. Because of the potential for serious side effects in nursing infants due to tetracyclines, a decision should be made whether to discontinue nursing or discontinue Borymycin, taking into account the importance of the drug to the mother.
Use in children: Generally, Borymycin should not be used by children <12 years, unless other drugs are ineffective or are contraindicated, because it may cause permanent discoloration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.