Merck Sharp & Dohme


Zuellig Pharma
Concise Prescribing Info
Sugammadex Na
Reversal of neuromuscular blockade induced by rocuronium or vecuronium.
Dosage/Direction for Use
Routine reversal Adult Recommended dose: 4 mg/kg as single IV bolus inj if recovery has reached at least 1-2 post-tetanic counts (PTC) or 2 mg/kg as single IV bolus inj if spontaneous recovery has occurred up to at least the reappearance of T2 following rocuronium- or vecuronium-induced blockade. Childn & adolescent 2-17 yr 2 mg/kg as single IV bolus inj at reappearance of T2. Immediate reversal of rocuronium-induced blockade Adult 16 mg/kg as single IV bolus inj 3 min after bolus dose of rocuronium Br 1.2 mg/kg.
Special Precautions
Hypersensitivity reactions. Not be used for reversal of neuromuscular blockade induced by steroidal neuromuscular blockers other than rocuronium or vecuronium. Recurrence of neuromuscular blockade; light anesth; marked bradycardia. Delayed recovery time in CV disease, oedematous stage. Monitor resp function during recovery. Carefully monitor coagulation parameters in patients w/ known coagulopathies. ICU setting; patients on controlled Na diet. Not recommended in severe renal impairment including patients requiring dialysis. Severe hepatic impairment; hepatic impairment accompanied by coagulopathy. Pregnancy & lactation. Not recommended in term newborn infants & infants. Delayed recovery time in elderly.
Adverse Reactions
Airway anesth complication, anesthetic complication, procedural hypotension & complication; cough; hypersensitivity; dysgeusia
Drug Interactions
Potentially affected efficacy w/ toremifene, IV fusidic acid. Potentially affect efficacy of hormonal contraceptives.
ATC Classification
V03AB35 - sugammadex ; Belongs to the class of antidotes. Used to reverse neuromuscular blockade caused by rocuronium or vecuronium.
Bridion soln for inj (vial) 100 mg/mL
2 mL x 10 × 1's;5 mL x 10 × 1's
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